N-[2-(pyridine-4-carbonylamino)ethyl]pyridine-4-carboxamide synthesis
3synthesis methods
- Product Name:N-[2-(pyridine-4-carbonylamino)ethyl]pyridine-4-carboxamide
- CAS Number:6631-22-7
- Molecular formula:C14H14N4O2
- Molecular Weight:270.29
Yield:6631-22-7 87%
Reaction Conditions:
Stage #1: pyridine-4-carboxylic acid;ethylenediaminewith triethylamine in N,N-dimethyl-formamide at 20; for 3 h;Inert atmosphere;
Stage #2: with 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide in N,N-dimethyl-formamide at 0 - 20; for 48 h;
References:
Brown, Sarah D.;Trotter, Katherine D.;Sutcliffe, Oliver B.;Plumb, Jane A.;Waddell, Bruce;Briggs, Naomi E. B.;Wheate, Nial J. [Dalton Transactions,2012,vol. 41,# 37,p. 11330 - 11339]
