Cyclopropanecarboxylic acid, 1-[(trifluoroacetyl)amino]- (9CI) synthesis
- Product Name:Cyclopropanecarboxylic acid, 1-[(trifluoroacetyl)amino]- (9CI)
- CAS Number:669066-98-2
- Molecular formula:C6H6F3NO3
- Molecular Weight:197.11
383-63-1
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$10.00/25g
22059-21-8
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$14.00/1g
669066-98-2
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$45.00/10mg
Yield:669066-98-2 87%
Reaction Conditions:
with triethylamine in methanol at 20; for 24 h;Inert atmosphere;
Steps:
A-1.A
ΓΑ1 l-(2,2,2-Trifluoro-acetylamino)-cyclopropanecarboxylic acid1-Amino-cyclopropanecarboxylic acid (2.483 g, 23.8 mmol) was added to MeOH (60 ml) to give a white suspension. Et3N (2.65 g, 3.65 ml, 26.2 mmol) and trifluoro-acetic acid ethyl ester (3.72 g, 3.12 ml, 26.2 mmol) were added and the mixture was stirred at RT. After 24 h, it was poured onto ice, acidified with IN HCl and extracted four times with EtOAc. The organic layer was washed once with water and once with IN HCl, dried over MgS04, filtered and evaporated; the residue formed was dried in vacuo to give the title compound (4.07 g, 87%) as colorless solid. MS: 196.0 (M-H~).
References:
WO2012/101011,2012,A2 Location in patent:Page/Page column 44
383-63-1
465 suppliers
$10.00/25g
68781-13-5
147 suppliers
$33.00/5g
669066-98-2
22 suppliers
$45.00/10mg
383-64-2
68 suppliers
$31.00/5g
22059-21-8
437 suppliers
$14.00/1g
669066-98-2
22 suppliers
$45.00/10mg
22059-21-8
437 suppliers
$14.00/1g
407-25-0
447 suppliers
$9.00/1g
669066-98-2
22 suppliers
$45.00/10mg