1-Aminocyclopropanecarboxylic acid
- CAS No.
- 22059-21-8
- Chemical Name:
- 1-Aminocyclopropanecarboxylic acid
- Synonyms
- 1-AMINOCYCLOPROPANE-1-CARBOXYLIC ACID;ACC;Ac3c;1-AMinocyclopropane-1-carboxylate;H-ACPC-OH;AMinocyclopropanecarboxylic acid;Cyclopropanecarboxylic acid, 1-amino-;1-AMINO-1-CYCLOPROPANECARBOXYLIC ACID;1-Aminocyclopropane-1-carboxylic acid (ACC);Acpc-OH
- CBNumber:
- CB6401146
- Molecular Formula:
- C4H7NO2
- Molecular Weight:
- 101.1
- MDL Number:
- MFCD00009944
- MOL File:
- 22059-21-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 229-231 °C (lit.) |
|---|---|
| Boiling point | 189.47°C (rough estimate) |
| Density | 1.2245 (rough estimate) |
| refractive index | 1.4340 (estimate) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly), Water (Slightly) |
| form | Powder and Granules |
| pka | 2.29±0.20(Predicted) |
| color | White to off-white |
| Water Solubility | Soluble in water. |
| BRN | 2076413 |
| Stability | Store in freezer at -20°C |
| InChI | InChI=1S/C4H7NO2/c5-4(1-2-4)3(6)7/h1-2,5H2,(H,6,7) |
| InChIKey | PAJPWUMXBYXFCZ-UHFFFAOYSA-N |
| SMILES | C1(N)(C(O)=O)CC1 |
| CAS DataBase Reference | 22059-21-8(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | 3K9EJ633GL |
| UNSPSC Code | 12352209 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36-37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | GZ1110000 | |||||||||
| Hazard Note | Irritant | |||||||||
| HS Code | 29213000 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| REACH Registrations | Active | |||||||||
| NFPA 704 |
|
1-Aminocyclopropanecarboxylic acid price More Price(88)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 149101-M | 1-Aminocyclopropane-1-carboxylic Acid - CAS 22059-21-8 - Calbiochem An agonist for the glycine modulatory site of the N-methyl-D-aspartate (NMDA) receptor complex. | 22059-21-8 | 250mg | $147 | 2026-04-30 | Buy |
| Sigma-Aldrich | 149101-M | 1-Aminocyclopropane-1-carboxylic Acid - CAS 22059-21-8 - Calbiochem An agonist for the glycine modulatory site of the N-methyl-D-aspartate (NMDA) receptor complex. | 22059-21-8 | 1g | $342 | 2026-04-30 | Buy |
| TCI Chemical | A1178 | 1-Aminocyclopropanecarboxylic Acid >97.0%(T) | 22059-21-8 | 1g | $76 | 2026-04-30 | Buy |
| TCI Chemical | A1178 | 1-Aminocyclopropanecarboxylic Acid >97.0%(T) | 22059-21-8 | 5g | $178 | 2026-04-30 | Buy |
| Cayman Chemical | 16132 | 1-Aminocyclopropanecarboxylic Acid ≥98% | 22059-21-8 | 100mg | $36 | 2026-04-30 | Buy |
1-Aminocyclopropanecarboxylic acid Chemical Properties,Uses,Production
Description
1-
Chemical Properties
Crystalline
Uses
1-Aminocyclopropane-1-carboxylic Acid is a plant growth regulator. It is an NMDA agonist acting at the glycine site.
Uses
1-Aminocyclopropane-1-carboxylic Acid is an intermediate in the conversion of methionine to ethylene during the ripening in apples. It also plays an important role in the biosynthesis of the plant hormone ethylene.1-Aminocyclopropane-1-carboxylic Acid is shown to block convulsions and death produced by NMDA exposure, significantly reducing seizure induction and cell death of NMDA-treated hippocampal neurons. 1-Aminocyclopropane-1-carboxylic Acid is produced endogenously in the tomato and other higher plants as a product of the action of 1-aminocyclopropane-1-carboxylic acid synthase in the biosynthesis of ethylene.
Definition
ChEBI: 1-aminocyclopropanecarboxylic acid is a non-proteinogenic alpha-amino acid consisting of cyclopropane having amino and carboxy substituents both at the 1-position. It has a role as a plant metabolite and a member of ethylene releasers. It is a monocarboxylic acid and a non-proteinogenic alpha-amino acid. It is functionally related to a cyclopropanecarboxylic acid. It is a conjugate acid of a 1-aminocyclopropanecarboxylate. It is a tautomer of a 1-aminocyclopropanecarboxylic acid zwitterion.
Application
1-aminocyclopropanecarboxylic acid (ACC) is used in the following ways:
(1) Organic synthesis. It is used for the preparation of vinyls and for the formation of imine compounds by decarboxylation with triketones.
(2) Used as a substrate for the determination of ACC deaminase activity for the study of the growth-promoting effects of endophytic isolates obtained from fern roots and cucurbit seeds.
(3) Used as an ethylene precursor to study the effect of high ethylene concentration on lateral root density (LRD) in sorghum brown midrib (bmr) mutants.
(4) Used to study the effect of glycine on the antidepressant and anxiolytic effects of ACC in rats.
Production Methods
ACC is produced through an industrial process that typically begins with preparation of a suitably protected amino-acid precursor, followed by a controlled cyclopropanation step that forms the strained three-membered ring while suppressing rearrangements and over-alkylation. Once the cyclopropane framework is established, deprotection and purification steps yield the free amino acid, with downstream operations centred on crystallisation, solvent removal, and multi-stage filtration to meet agrochemical specifications for optical purity, residual solvents, and trace by-products.
Synthesis Reference(s)
Synthetic Communications, 18, p. 141, 1988 DOI: 10.1080/00397918808077338
Synthesis, p. 127, 1984
General Description
1-Aminocyclopropanecarboxylic acid is a member of 1-aminocycloalkanecarboxylic acids.
Biochem/physiol Actions
1-Aminocyclopropanecarboxylic acid (ACC) exhibits anticonvulsant, anxiolytic, anti-addictive, neuroprotective and antidepressant-like effects in rats and mice. ACC does not affect memory or learning processes.
Mechanism of action
As an ethylene releasing substance it affects the growth and development of plants as well as their senescence.
References
[1] A B BLEECKER H K. Ethylene: a gaseous signal molecule in plants.[J]. Annual review of cell and developmental biology, 2000, 16: 1-18. DOI: 10.1146/annurev.cellbio.16.1.1
[2] R NAHUM-LEVY. Putative partial agonist 1-aminocyclopropanecarboxylic acid acts concurrently as a glycine-site agonist and a glutamate-site antagonist at N-methyl-D-aspartate receptors.[J]. Molecular Pharmacology, 1999, 56 6: 1207-1218. DOI: 10.1124/mol.56.6.1207
Pesticide Type
Herbicide; Plant Growth Regulator
1-Aminocyclopropanecarboxylic acid Preparation Products And Raw materials
Raw materials
1of4
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Wuhan Luyi New Material Co., Ltd. | 027-81360608 13971310049 | 109321999@qq.com | China | 80 | 58 |
| Shanghai Yurlic Chemical S&T Co.Ltd. | 021-37285141 15618858630 | yancf@yulibiotech.com | China | 170 | 58 |
| Aikon International Limited | 025-58859352 15955137747 | sales01@aikonchem.com | China | 16021 | 58 |
| CE Pharm Co.,Ltd | 15317222985 | xin.yu@cepharm.cn | China | 160 | 58 |
| Changzhou Mailekang Pharmaceutical Technology Co., Ltd. | 0519-69655553 13961137915 | mlksales@126.com | China | 62 | 58 |
| Changzhou Huanling Chemical Co., Ltd. | 89803005 18206112582 | info@huanlingchem.com | China | 983 | 68 |
| Hubei Yiling Biotechnology Co., Ltd | 027-65526929 17771822910 | hxry001@foxmail.com | China | 50 | 58 |
| Shandong Scientific Research Pharmaceutical Co., Ltd | 13053388919 | 3908585847@qq.com | China | 83 | 58 |
| Qingdao Baiyi Chemical Co., Ltd | 13053388919; 13053388919 | 1454485610@qq.com | China | 171 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
Related articles
- 1-Aminocyclopropanecarboxylic Acid: Plant Ethylene Precursor and Procognitive Agent
- 1-Aminocyclopropanecarboxylic acid, mediates ethylene-dependent growth and acts as a procognitive partial agonist at NMDA glyc....
- Jan 5,2026
View Lastest Price from 1-Aminocyclopropanecarboxylic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-11 | 1-Aminocyclopropanecarboxylic acid
22059-21-8
|
1kg | 99% | 1000kg | WUHAN FORTUNA CHEMICAL CO., LTD | ||
 |
2026-09-02 | 1-Aminocyclopropanecarboxylic acid
22059-21-8
|
$1.20-34.00 | 1kg | 99% | Henan Fengda Chemical Co., Ltd | ||
 |
2026-08-07 | 1-Aminocyclopropanecarboxylic acid
22059-21-8
|
$1.00 | 1KG | 99% | 200000KG | Shaanxi Dideu Medichem Co. Ltd |
-
- 1-Aminocyclopropanecarboxylic acid
22059-21-8
- 99%
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- 1-Aminocyclopropanecarboxylic acid
22059-21-8
- $1.20-34.00
- 99%
- Henan Fengda Chemical Co., Ltd
-
- 1-Aminocyclopropanecarboxylic acid
22059-21-8
- $1.00
- 99%
- Shaanxi Dideu Medichem Co. Ltd
