Carbamic acid, (1-methyl-3-pyrrolidinyl)-, 1,1-dimethylethyl ester (9CI) synthesis
- Product Name:Carbamic acid, (1-methyl-3-pyrrolidinyl)-, 1,1-dimethylethyl ester (9CI)
- CAS Number:748184-01-2
- Molecular formula:C10H20N2O2
- Molecular Weight:200.28
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Yield:748184-01-2 146 mg
Reaction Conditions:
with sodium tetrahydroborate in methanol;water at 20;
Steps:
15.a a) tert-butyl (1-methylpyrrolidin-3-yl)carbamate
3-Boc-aminopyrrolidine (150 mg, 0.81 mmol) was dissolved in MeOH (5 mL)37% aqueous formaldehyde solution (0.26 mL) and sodium borohydride (92 mg, 2.43 mmol) were added in that order.Stir at room temperature overnight, and distill off the solvent under reduced pressure.The obtained oil was dissolved in chloroform (40 mL) and washed sequentially with brine (40 mL).Washed with water (40mL), anhydrous Na2SO4,Concentrate to 146 mg of a white solid.
References:
CN108727343,2018,A Location in patent:Paragraph 0325; 0328; 0329