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864226-30-2

2-Chloro-5-oxo-5,6,7,8-tetrahydroquinoline-3-carbonitrile synthesis

3synthesis methods
2,5-dioxo-1,2,5,6,7,8-hexahydroquinoline-3-carbonitrile

106551-67-1
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2-Chloro-5-oxo-5,6,7,8-tetrahydroquinoline-3-carbonitrile

864226-30-2
8 suppliers
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Yield:864226-30-2 72%

Reaction Conditions:

with thionyl chloride;N,N-dimethyl-formamide in dichloromethane; for 16 h;Inert atmosphere;Reflux;Vilsmeier Reaction;

References:

Kong, Deyu;Xue, Tao;Guo, Bin;Cheng, Jianjun;Liu, Shunyin;Wei, Jianhai;Lu, Zhengyu;Liu, Haoran;Gong, Guoqing;Lan, Tian;Hu, Wenhao;Yang, Yushe [Journal of Medicinal Chemistry,2019,vol. 62,# 6,p. 3088 - 3106] Location in patent:supporting information