tert-butyl 4-[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]piperidine-1-carboxylate synthesis
- Product Name:tert-butyl 4-[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]piperidine-1-carboxylate
- CAS Number:889865-34-3
- Molecular formula:C22H34BNO5
- Molecular Weight:403.32
109384-19-2
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269409-70-3
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889865-34-3
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$98.00/100mg
Yield:889865-34-3 264 mg
Reaction Conditions:
with di-isopropyl azodicarboxylate;triphenylphosphine in tetrahydrofuran at 20;Inert atmosphere;Temperature;
Steps:
2.1 Step 1: tert-butyl 4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2- yl)phenoxy)piperidine-1-carboxylate
To a 100 ml round bottom flask were added under an argon atmosphere 4- hydroxyphenylboronic acid pinacol ester (257 mg, 1.168 mmol), tert-butyl 4- hydroxypiperidine-1-carboxylate (264 mg, 1.285 mmol), PPh3 (337 mg, 1.285 mmol) and THF (5 ml). DIAD (0.250 ml, 1.285 mmol) was added dropwise and the RM was stirred at RT overnight. The RM was pourred into a mixture of EtOAc and an aq. sat. solution of Na2CO3, the aq. phase was extracted with EtOAc, the combined organic phases were washed with brine, dried over MgSO4 and the residue was purified by chromatography on silica gel eluting with EtOAc (from 0 % to 20 %) in CHX, yielding the title compound as a solid (264 mg). Method D: Rt = 1.49 min; [M-tBu+H]+= 348.
References:
WO2021/55295,2021,A1 Location in patent:Page/Page column 302; 303; 443; 444
308386-38-1
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73183-34-3
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889865-34-3
41 suppliers
$98.00/100mg
73183-34-3
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346617-98-9
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889865-34-3
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109384-19-2
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![2-(4-BROMO-PHENYL)-4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLANE](/CAS/GIF/68716-49-4.gif)
68716-49-4
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889865-34-3
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$98.00/100mg
109384-19-2
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460-00-4
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889865-34-3
41 suppliers
$98.00/100mg