(6-CHLORO-PYRIDIN-3-YL)-OXO-ACETIC ACID ETHYL ESTER synthesis
- Product Name:(6-CHLORO-PYRIDIN-3-YL)-OXO-ACETIC ACID ETHYL ESTER
- CAS Number:902837-55-2
- Molecular formula:C9H8ClNO3
- Molecular Weight:213.62
53939-30-3
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902837-55-2
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Yield:-
Reaction Conditions:
Stage #1: 5-bromo-2-chloropyridinewith n-butyllithium in tetrahydrofuran at -78;
Stage #2: oxalic acid diethyl ester in tetrahydrofuran at -78;
References:
Morales-Ramos, ángel I.;Li, Yue H.;Hilfiker, Mark;Mecom, John S.;Eidam, Patrick;Shi, Dongchuan;Tseng, Pei-San;Brooks, Carl;Zhang, David;Wang, Ning;Jaworski, Jon-Paul;Morrow, Dwight;Fries, Harvey;Edwards, Richard;Jin, Jian [Bioorganic and Medicinal Chemistry Letters,2011,vol. 21,# 10,p. 2806 - 2811] Location in patent:scheme or table