AKOS B018374 synthesis

Yield:4818-22-8 85%

Reaction Conditions:

with potassium tert-butylate in ethanol; for 19 h;Inert atmosphere;Reflux;

Steps:

3

To a reaction container purged with nitrogen, rhodanine (5.33 g), 2,4-dimethylbenzaldehyde (5.37 g) and ethanol (40 ml) were placed and stirred. tert-Butoxy potassium (1.12 g) and ethanol (20 ml) were added and the mixture was heated under reflux for 19 hours while stirring. The mixture was cooled to room temperature and precipitated crystal was collected by filtration and then subjected to soak cleaning in ethanol to obtain Exemplary Compound No. 28 (8.5 g (yield 85%)) as a slightly yellowish white crystal.

References:

US2012/315576,2012,A1 Location in patent:Page/Page column 24