artemisic acid synthesis
- Product Name:artemisic acid
- CAS Number:80286-58-4
- Molecular formula:C15H22O2
- Molecular Weight:234.33
125184-95-4
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80286-58-4
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Yield:80286-58-4 100%
Reaction Conditions:
with Jones reagent in acetone at 20;
Steps:
3.3.2.3
To a solution of 0.2 mmol of 6 in 1 mL acetone at 0° C. were added several drops of Jones Reagent (1.4M CrO3: 2.2 M H2SO4: water). The reaction mixture was allowed to warm to room temperature and stirred until the starting material 6 was consumed. To the reaction was added water and CH2Cl2. The organic layer was washed with water and dried over MgSO4. The solvent was removed in vacuo to yield 2 in quantitative yield (LC/MS). Compound 2 can readily be converted to DHAA, 3, as described by Roth and Acton, J. Chem. Ed., 68:7, 612-613 or by catalytic hydrogenation (Example 4).
References:
Amyris Biotechnologies US2006/270863, 2006, A1 Location in patent:Page/Page column 19
64-17-5
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50-99-7
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80286-58-4
179 suppliers
$34.00/10mg
64-17-5
758 suppliers
$10.00/50g
80286-58-4
179 suppliers
$34.00/10mg
92692-39-2
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125184-95-4
14 suppliers
inquiry