Welcome to chemicalbook!
Chinese English Japanese Germany Korea
010-86108875
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook CAS DataBase List Chlorophacinone
3691-35-8

Chlorophacinone synthesis

3synthesis methods
Chlorophacinone is produced commercially through a multi-step chemical synthesis that centres on the preparation of 2-[(4-chlorophenyl)phenylacetyl]-1,3-indandione. The process begins with the condensation of 4-chlorobenzaldehyde and benzene derivatives to form the key intermediate, which is then acylated with phenylacetic acid derivatives under controlled conditions. This yields the indandione structure with the desired chlorinated phenyl substituent. The synthesis requires precise temperature control and purification steps to ensure high yield and product purity.
-

Yield:-

Steps:

Multi-step reaction with 2 steps
1: oxalyl dichloride / dichloromethane / 12 h / 25 °C
2: aluminum (III) chloride / dichloromethane / 12 h / 25 °C

References:

Csuk, Rene;Barthel, Alexander;Stroehl, Dieter [Zeitschrift fur Naturforschung, B: Chemical Sciences,2011,vol. 66,# 1,p. 95 - 97]

FullText

Chlorophacinone Related Search: