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ChemicalBook CAS DataBase List Choline chloride
67-48-1

Choline chloride synthesis

3synthesis methods
Choline chloride is produced commercially primarily via the reaction of ethylene oxide, hydrochloric acid, and trimethylamine. Ethylene oxide is reacted with trimethylamine to form choline hydroxide. The choline hydroxide is then neutralised with hydrochloric acid to produce choline chloride. The resulting choline chloride is purified to remove any impurities.
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Yield:67-48-1 98%

Reaction Conditions:

in methanol;acetonitrile at 70; for 14 h;Inert atmosphere;

References:

Lu, Cuifen;Zhang, Li;Yang, Guichun;Chen, Zuxing [Chinese Journal of Chemistry,2010,vol. 28,# 12,p. 2469 - 2473] Location in patent:experimental part Gao, Meng;Lu, Cui Fen;Yang, Gui Chun;Chen, Zu Xing [Chinese Chemical Letters,2011,vol. 22,# 7,p. 823 - 826] Location in patent:experimental part

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