
DICLOFENAC METHYL ESTER synthesis
- Product Name:DICLOFENAC METHYL ESTER
- CAS Number:15307-78-5
- Molecular formula:C15H13Cl2NO2
- Molecular Weight:310.18

67-56-1
776 suppliers
$7.30/5ml-f

15307-86-5
382 suppliers
$48.00/25g

15307-78-5
100 suppliers
$35.00/10mg
Yield: 96%
Reaction Conditions:
with sulfuric acid for 0.25 h;Reflux;
Steps:
3.1.4.2. Diclofenac Methyl Ester (2)
Diclofenac acid (5 g) was dissolved in methanol (80 mL)with stirring and sulfuric acid (3 mL) was added drop wisewith continuous stirring and the mixture was heated underreflux for 15 min. After completion of the reaction (TLCanalysis), it was cooled to room temperature and poured ontocrushed ice (250 g) to obtain crystalline solid (2) which wasfiltered, washed with water followed by 5% sodium hydrogencarbonate solution, finally with water and dried in air.
References:
Shah, Shazia;Arshia;Kazmi, Nida Siraj;Jabeen, Almas;Khan, Khalid Mohammed;Raza, Abeer;Faheem, Aisha;Dastagir, Nida;Ahmed, Tariq;Ahmed, Shakil;Perveen, Shahnaz [Medicinal Chemistry,2018,vol. 14,# 7,p. 674 - 687]

57486-69-8
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$6.00/1g

608-31-1
315 suppliers
$12.00/25g

15307-78-5
100 suppliers
$35.00/10mg

66370-75-0
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608-31-1
315 suppliers
$12.00/25g

15307-78-5
100 suppliers
$35.00/10mg

15307-79-6
891 suppliers
$14.00/5g

74-88-4
352 suppliers
$15.00/10g

15307-78-5
100 suppliers
$35.00/10mg

15307-86-5
382 suppliers
$48.00/25g

18107-18-1
214 suppliers
$33.00/5g

15307-78-5
100 suppliers
$35.00/10mg