FMOC-SARCOSINE MONOHYDRATE synthesis
- Product Name:FMOC-SARCOSINE MONOHYDRATE
- CAS Number:77128-70-2
- Molecular formula:C18H17NO4
- Molecular Weight:311.33
107-97-1
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82911-69-1
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$7.00/25g
77128-70-2
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Yield:77128-70-2 98%
Reaction Conditions:
with sodium hydrogencarbonate in 1,4-dioxane;water at 20; for 5 h;
Steps:
(9-Fluorenylmethyloxycarbonyl(methyl)amino)acetic acid (S7)
To a solution of sarcosine (500 mg, 5.61 mmmol) in saturated NaHCO3 (10 ml) were added solution of Fmoc-OSu (1.99 g, 5.90 mmol) in 1,4-dioxane (10 ml) and the mixture was stirred for 5 h. Saturated NH4Cl and AcOEt was added to the solution and organic layer was washed with brine, dried over MgSO4 and evaporated in vacuo. The residue was purified with column chromatography (CHCl3:MeOH = 80:20 v/v) to give S7 (1.71 g, 5.49 mmol, 98%) as a white solid.
References:
Sato, Ryota;Oyama, Kie;Konno, Hiroyuki [Tetrahedron,2018,vol. 74,# 42,p. 6173 - 6181] Location in patent:supporting information
28920-43-6
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637-96-7
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$45.00/250mg
77128-70-2
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29022-11-5
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77128-70-2
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50-00-0
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29022-11-5
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77128-70-2
206 suppliers
$10.00/5g