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18162-48-6872-50-4Methylene ChloridenaphthaleneTHFTitanium Dioxide
ChemicalBook CAS DataBase List Isoprocarb
2631-40-5

Isoprocarb synthesis

3synthesis methods
Isoprocarb is commercially produced via a concise 2–3 step synthesis that begins with the preparation of 2-isopropylphenyl chloroformate by reacting 2-isopropylphenol with phosgene in toluene in the presence of a catalytic amount of DMF. The key carbamoylation occurs through nucleophilic addition of methylamine to the chloroformate intermediate under controlled pH to form the methylcarbamate linkage, minimizing hydrolysis. Final purification via vacuum distillation or crystallisation from hexane yields isoprocarb.
88-69-7 Synthesis
2-Isopropylphenol

88-69-7
190 suppliers
$5.00/5 g

N-Methylurethane

105-40-8
88 suppliers
$40.00/250mg

Isoprocarb

2631-40-5
155 suppliers
$98.30/50mg

-

Yield:-

Reaction Conditions:

with trichlorophosphate in toluene

Steps:

9 2-ISOPROPYLPHENYL N-METHYLCARBAMATE
EXAMPLE 9 2-ISOPROPYLPHENYL N-METHYLCARBAMATE To a solution of 2-isopropylphenol (1.38 g, 0.01 mole) and ethyl N-methylcarbamate (1.03 g, 0.01 mole) in toluene (10 ml), was added phosphoryl chloride (1.54 g, 0.01 mole) and refluxed for six hours. The reaction mixture was worked up as described earlier to give 2-isopropylphenyl N-methylcarbamate as a solid, crystallized from petroleum ether, m.p. 88oC to 93oC.

References:

Council of Scientific and, Industrial Research EP446514, 1991, A1

FullText

88-69-7 Synthesis
2-Isopropylphenol

88-69-7
190 suppliers
$5.00/5 g

METHYLISOCYANATE 1 X 500MG NEAT

624-83-9
0 suppliers
inquiry

Isoprocarb

2631-40-5
155 suppliers
$98.30/50mg

References
88-69-7 Synthesis
2-Isopropylphenol

88-69-7
190 suppliers
$5.00/5 g

Isoprocarb

2631-40-5
155 suppliers
$98.30/50mg

References

Isoprocarb Related Search:

4-Aminobenzoic acid Benzocaine (-)-Menthyl chloroformate