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ChemicalBook CAS DataBase List IverMectin B1 Aglycon
73162-95-5

IverMectin B1 Aglycon synthesis

2synthesis methods
-

Yield:73162-95-5 80% ,71837-27-9 20%

Reaction Conditions:

with sulfuric acid;water

Steps:

1.1 Ivermectin aglycone synthesis

Ivermectin aglycone (22,23-dihydroavermectin B1 aglycone) is obtained from ivermectin by acid hydrolysis (1% of sulphuric acid). Ivermectin aglycone is purified by HPLC according to the method described by Alvinerie et al. (Ann Rech Vet, (1987), 18, 269- 274).

References:

WO2013/57222,2013,A2 Location in patent:Page/Page column 13

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