N-BOC-TRANS-4-CYANO-L-PROLINE METHYL ESTER synthesis
- Product Name:N-BOC-TRANS-4-CYANO-L-PROLINE METHYL ESTER
- CAS Number:194163-91-2
- Molecular formula:C12H18N2O4
- Molecular Weight:254.28
84520-67-2
60 suppliers
$14.00/250mg
194163-91-2
42 suppliers
$323.00/250mg
Yield:194163-91-2 205 mg (11%)
Reaction Conditions:
in dimethyl sulfoxide;
Steps:
B Step B
Step B (4R)-1-(tert-Butyloxycarbonyl)-4-cyano-L-Proline Methyl Ester A mixture of (4R)-1-(tert-butyloxycarbonyl)-4-(methane-sulfonyloxy)-L-proline methyl ester (2.31 g, 7.14 mmol) and sodium cyanide (3.5 g, 71.4 mmol) in dry dimethylsulfoxide (46 mL) was stirred for 24 hours at 55° C. under a nitrogen atmosphere. The cooled reaction mixture was diluted with ethyl acetate, washed with water (2*), saturated brine solution, dried (MgSO4), and evaporated. The crude product mixture was subjected to flash silica gel chromatography eluding with 15% acetone/hexane. Fractions containing the desired nitrile were combined and evaporated to afford a colorless oil; yield 205 mg (11%).
References:
US5821261,1998,A
773837-37-9
0 suppliers
inquiry
88043-21-4
113 suppliers
$17.00/1g
194163-91-2
42 suppliers
$323.00/250mg
151-50-8
0 suppliers
$43.37/100g
![1,2-Pyrrolidinedicarboxylic acid, 4-[(Methylsulfonyl)oxy]-, 1-(1,1-diMethylethyl) 2-Methyl ester, (2S,4S)-](/CAS/20150408/GIF/121147-93-1.gif)
121147-93-1
3 suppliers
inquiry
194163-91-2
42 suppliers
$323.00/250mg
13726-69-7
439 suppliers
$5.00/1g
194163-91-2
42 suppliers
$323.00/250mg
51-35-4
876 suppliers
$6.00/5g
194163-91-2
42 suppliers
$323.00/250mg