Pipemidic acid synthesis
- Product Name:Pipemidic acid
- CAS Number:51940-44-4
- Molecular formula:C14H17N5O3
- Molecular Weight:303.32
51940-43-3
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51940-44-4
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Yield:-
Reaction Conditions:
with sodium hydroxide
Steps:
43 5,8-Dihydro-8-ethyl-2-(1-Piperazinyl)-5-oxopyrido [2,3-d]pyrimidine-6-carboxylic acid (compound 1).
EXAMPLE 43 5,8-Dihydro-8-ethyl-2-(1-Piperazinyl)-5-oxopyrido [2,3-d]pyrimidine-6-carboxylic acid (compound 1). Ethyl 5,8-dihydro-8-ethyl-5-oxo-2-(1-piperazinyl) pyrido[2,3-d]pyrimidine-6-carboxylate (5.0 g) was dissolved in 30 ml of a 7% aqueous solution of sodium hydroxide by heating at 90°C for 20 minutes. After cooling, the resulting solution was neutralized with acetic acid to yield a precipitate which was collected, and recrystallized from dimethylformamide. There is obtained 4.3 g of the product m.p 253° - 255°C.
References:
US3962443,1976,A
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52070-73-2
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51940-44-4
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$50.00/100mg
142-63-2
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19572-11-3
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51940-44-4
196 suppliers
$50.00/100mg
7732-18-5
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$13.50/100ML
51940-44-4
196 suppliers
$50.00/100mg