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ChemicalBook CAS DataBase List Prasugrel Impurity 1
601525-80-8

Prasugrel Impurity 1 synthesis

2synthesis methods
-

Yield:601525-80-8 96%

Reaction Conditions:

Stage #1: N-trityl-4,5,6,7-tetrahydrothieno[2,3-c]pyridinewith n-butyllithium in tetrahydrofuran;hexane at -10 - 0; for 2 h;Inert atmosphere;
Stage #2: with Trimethyl borate in tetrahydrofuran;hexane at -10; for 1.5 h;
Stage #3: with sodium hydrogencarbonate in ethyl acetate;

References:

Ou, Wenhua;Yi, Weiyin;Liu, Feng;Pan, Xianhua;Peng, Xijiang [Journal of Chemical Research,2013,vol. 37,# 6,p. 369 - 371]

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