Prasugrel Impurity 1 synthesis
- Product Name:Prasugrel Impurity 1
- CAS Number:601525-80-8
- Molecular formula:C26H24BNO2S
- Molecular Weight:425.35
![4,5,6,7-Tetrahydro-5-(triphenylmethyl)thieno[3,2-c]pyridine](/CAS/GIF/109904-25-8.gif)
109904-25-8
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601525-80-8
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Yield:601525-80-8 96%
Reaction Conditions:
Stage #1: N-trityl-4,5,6,7-tetrahydrothieno[2,3-c]pyridinewith n-butyllithium in tetrahydrofuran;hexane at -10 - 0; for 2 h;Inert atmosphere;
Stage #2: with Trimethyl borate in tetrahydrofuran;hexane at -10; for 1.5 h;
Stage #3: with sodium hydrogencarbonate in ethyl acetate;
References:
Ou, Wenhua;Yi, Weiyin;Liu, Feng;Pan, Xianhua;Peng, Xijiang [Journal of Chemical Research,2013,vol. 37,# 6,p. 369 - 371]
![4,5,6,7-Tetrahydrothieno[3,2,c] pyridine hydrochloride](/CAS/GIF/28783-41-7.gif)