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18162-48-6872-50-4Methylene ChloridenaphthaleneTHFTitanium Dioxide
ChemicalBook CAS DataBase List Propiconazole
60207-90-1

Propiconazole synthesis

5synthesis methods
The commercial production of propiconazole involves a multi-step chemical synthesis that typically begins with ethanone-1-(2,4-dichlorophenyl), which undergoes condensation with 1,2-pentanediol to form a dioxolane intermediate. This intermediate is then brominated in dichloromethane to produce a bromomethyl derivative, which finally undergoes nucleophilic substitution with a sodium triazole salt in dimethyl sulfoxide at elevated temperatures to yield propiconazole.
1,2-Pentanediol

5343-92-0
538 suppliers
$14.00/1g

1-(2,4-DICHLOROLPHENYL)-2-(1H-1,2,4-TRIAZOLE-1-YL)-ETHANONE

58905-16-1
53 suppliers
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Propiconazole

60207-90-1
372 suppliers
$28.00/100mg

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Yield:60207-90-1 98.9%

Reaction Conditions:

with toluene-4-sulfonic acid in cyclohexane; for 8 h;Reflux;

Steps:

1.2 2) Synthesis of 1-[2-(2,4-Dichlorophenyl)-4-propyl-1,3-dioxolane-2-methyl]-1hydro-1,2,4triazole :

Add 125g of (2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-yl)-1-ethanone obtained in the previous step into the four-neck flask,Then add 500g of cyclohexane,Catalyst p-toluenesulfonic acid,65g of 1,2-pentanediol,Warm up to reflux,Reflux for 8h,After the response is qualified,Add 300g of water to the reaction for washing,Stratification,Oil phase negative pressure desolventizing,Obtain 1-[2-(2,4-Dichlorophenyl)-4-propyl-1,3-dioxolane-2-methyl]-1hydro-1,2,4triazole or propane Azole 163.6g,The content is 99.2%,The yield was 98.9%.

References:

CN113336715,2021,A Location in patent:Paragraph 0020; 0022

2',4'-Dichloroacetophenone

2234-16-4
428 suppliers
$6.00/25g

Propiconazole

60207-90-1
372 suppliers
$28.00/100mg

References
541-73-1 Synthesis
1,3-Dichlorobenzene

541-73-1
409 suppliers
$20.00/25G

Propiconazole

60207-90-1
372 suppliers
$28.00/100mg

References
137958-96-4 Synthesis
1-(2,4-DICHLOROPHENYL)-2-HYDROXYETHANONE

137958-96-4
30 suppliers
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Propiconazole

60207-90-1
372 suppliers
$28.00/100mg

References
1,2-Pentanediol

5343-92-0
538 suppliers
$14.00/1g

Propiconazole

60207-90-1
372 suppliers
$28.00/100mg

References

Propiconazole Related Search:

Dichlorodiphenylsilane 1,4-Dioxane Methylparaben trans-4-Aminocyclohexanol 1-(2,4-DICHLORO-PHENYL)-ETHYLAMINE 1-METHYL-1,2,4-TRIAZOLE 2-Chlorophenethylamine Parathion-methyl 4-Chlorophenethylamine 1,3-Dioxolane