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ChemicalBook CAS DataBase List (PYRROLIDIN-1-YLCARBONOTHIOYL)THIO]ACETIC ACID
20069-28-7

(PYRROLIDIN-1-YLCARBONOTHIOYL)THIO]ACETIC ACID synthesis

3synthesis methods
-

Yield:20069-28-7 123.73 g

Reaction Conditions:

Stage #1: 1-methyl-piperazine;carbon disulfidewith potassium hydroxide in ethanol;water at 20; for 1 h;Cooling with ice;
Stage #2: chloroacetic acidwith sodium carbonate in ethanol;water; for 0.12 h;
Stage #3: with hydrazine hydrate;potassium hydroxide for 1 h;Reflux;

References:

Knak, Stefanie;Pfeiffer, Wolf-Diethard;Dollinger, Horst;Langer, Peter [Journal of Heterocyclic Chemistry,2015,vol. 52,# 2,p. 450 - 462]