Sucralose synthesis
- Product Name:Sucralose
- CAS Number:56038-13-2
- Molecular formula:C12H19Cl3O8
- Molecular Weight:397.63
105066-21-5
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Yield:56038-13-2 95%
Reaction Conditions:
with methanol;sodium methylate at 40 - 50; for 2 h;
Steps:
6
EXAMPLE 6 Synthesis of sucralose A mixture of 20 g of dry sucralose-6-acetate obtained from Example 5 and 70 ml of methanol was heated to from 40° C. to 50° C. When the reacting mixture became a clear solution, a small quantity of a 30% sodium methylate solution was added. After the mixture was stirred for 2 hours, methanol was removed under reduced pressure. The resultant mixture was diluted to a 30% mixture by adding a certain quantity of water, which was decolored and then filtered. The filtrate thus obtained was concentrated to a 65% solution, which was cooled to form crystallized sucralose. The obtained crystal was filtered and dried to give sucralose with a yield of over 95% and purity of over 98.0%.
References:
US2008/58508,2008,A1 Location in patent:Page/Page column 3
55832-20-7
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56038-13-2
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63648-81-7
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56038-13-2
797 suppliers
$5.00/100mg
63648-81-7
30 suppliers
$55.00/100mg
105066-21-5
9 suppliers
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56038-13-2
797 suppliers
$5.00/100mg
63648-78-2
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56038-13-2
797 suppliers
$5.00/100mg