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ChemicalBook CAS DataBase List Tetradifon
116-29-0

Tetradifon synthesis

3synthesis methods
Tetradifon is produced commercially through a multi-step synthesis involving chlorinated benzene derivatives and sulfonylation reactions, resulting in a stable organochlorine acaricide used in agriculture. The process begins with the preparation of 1,2,4-trichlorobenzene, which serves as a key intermediate. This compound undergoes sulfonylation with 4-chlorobenzenesulfonyl chloride to form the active ingredient tetradifon.
-

Yield:-

Steps:

Multi-step reaction with 4 steps
1: ethanolic NaOH-solution
2: aqueous hydrogen peroxide; acetic acid
3: iron; aqueous acetic acid

References:

Huisman et al. [Recueil des Travaux Chimiques des Pays-Bas,1958,vol. 77,p. 103,112, 114]

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