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ChemicalBook CAS DataBase List TRIFENMORPH
1420-06-0

TRIFENMORPH synthesis

7synthesis methods
Trifenmorph is commercially produced by reacting morpholine with trityl chloride to form N-tritylmorpholine. The synthesis involves the alkylation of morpholine, a cyclic amine, with trityl chloride (triphenylmethyl chloride) under controlled conditions, typically in the presence of a base such as triethylamine or sodium carbonate.
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Yield:-

Steps:

Multi-step reaction with 2 steps
1: dichloromethane / 20 °C / Schlenk technique
2: 5-(3-methoxy-3-methylbut-1-yn-1-yl)-1,3-bis(1-(3,5-bis(trifluoromethyl)-phenyl)-1H-1,2,3-triazol-4-yl)benzene / tetrahydrofuran / 72 h / 45 °C

References:

Beckendorf, Stephan;Asmus, Sören;Mück-Lichtenfeld, Christian;García Mancheño, Olga [Chemistry - A European Journal,2013,vol. 19,# 5,p. 1581 - 1585]

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