| Identification | Back Directory | [Name]
Propargyl-PEG8-t-butyl ester | [CAS]
2055014-96-3 | [Synonyms]
CAS_2055014-96-3
Propargyl-PEG8-Boc
Propargyl-PEG8-COOtBu
Propargyl-PEG8-t-Bu Ester
Propargyl-PEG7-CH2CH2COOtBu
Propargyl-PEG8-t-butyl ester
4,7,10,13,16,19,22,25-Octaoxaoctacos-27-ynoic acid, 1,1-dimethylethyl ester | [Molecular Formula]
C24H44O10 | [MDL Number]
MFCD28976700 | [MOL File]
2055014-96-3.mol | [Molecular Weight]
492.6 |
| Chemical Properties | Back Directory | [Boiling point ]
528.4±45.0 °C(Predicted) | [density ]
1.064±0.06 g/cm3(Predicted) | [solubility ]
Soluble in Water, DMSO, DCM, DMF | [form ]
Liquid | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Description]
Propargyl-PEG8-t-butyl ester is a PEG reagent with an alkyne group and a t-butyl group. The alkyne group enables the formation of triazole linkage with azide-bearing compounds or biomolecules; copper is required as a catalyst. The t-butyl group can be hydrolyzed under acidic conditions. The hydrophicility of the molecule is improved by having 8 units of PEG. | [Uses]
Propargyl-PEG7-Boc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. Propargyl-PEG8-Boc is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [IC 50]
PEGs; Alkyl/ether | [References]
[1] Noah Bell, et al. Compounds and methods for inhibiting phosphate transport. WO2012054110A2. |
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