| Identification | Back Directory | [Name]
Biotin-PEG2-Acid | [CAS]
1365655-89-5 | [Synonyms]
Biotin-PEG2-Acid
Biotin-PEG2-COOH
(+)-Biotin-PEG2-acid
(+)-Biotin-PEG2-CH2CH2COOH
Propanoic acid, 3-[2-[2-[[5-[(3aR,4R,6aS)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-1-oxopentyl]amino]ethoxy]ethoxy]-, rel- | [Molecular Formula]
C17H29N3O6S | [MDL Number]
MFCD22056305 | [MOL File]
1365655-89-5.mol | [Molecular Weight]
403.49 |
| Chemical Properties | Back Directory | [Boiling point ]
752.2±60.0 °C(Predicted) | [density ]
1.234±0.06 g/cm3(Predicted) | [solubility ]
Soluble in DMSO, DMF | [form ]
solid | [pka]
4.28±0.10(Predicted) | [color ]
White | [InChIKey]
SDOAIZRTYJIBBG-RMBTXETHNA-N | [SMILES]
C(O)(=O)CCOCCOCCNC(=O)CCCC[C@@H]1[C@]2([H])NC(=O)N[C@]2([H])CS1 |&1:18,19,25,r| |
| Hazard Information | Back Directory | [Description]
Biotin-PEG2-acid is reactive with amine-containing macromolecule. The hydrophilic PEG arm improves water solubility. The biotin groups serve as an affinity label towards the proteins avidin and streptavidin. | [Uses]
Biotin-PEG2-acid is a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Biotin-PEG2-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. | [IC 50]
PEGs; Non-cleavable Linker | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. DOI:10.1016/j.ebiom.2018.09.005 |
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