| Identification | Back Directory | [Name]
Biotin-PEG12-Acid | [CAS]
1621423-14-0 | [Synonyms]
Biotin-PEG12-Acid
(+)-Biotin-PEG12-acid
(+)-Biotin-PEG12-CH2CH2COOH
4,7,10,13,16,19,22,25,28,31,34,37-Dodecaoxa-40-azapentatetracontanoic acid, 45-[(3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-41-oxo- | [Molecular Formula]
C37H69N3O16S | [MDL Number]
MFCD08274601 | [MOL File]
1621423-14-0.mol | [Molecular Weight]
844.02 |
| Hazard Information | Back Directory | [Description]
Biotin-PEG12-acid is a biotin PEG linker containing a carboxylic acid group, it is reactive with amine moiety. The hydrophilic PEG spacer arm imparts water solubility that is transferred to the biotinylated molecule. | [Uses]
Biotin-PEG12-acid is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs | [References]
[1] Gadd MS, et al. Structural basis of PROTAC cooperative recognition for selective protein degradation. Nat Chem Biol. 2017 May;13(5):514-521. DOI:10.1038/nchembio.2329 |
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