| Identification | Back Directory | [Name]
3,6,9,12-Tetraoxatetradecan-1-ol, 14-bromo- | [CAS]
957205-14-0 | [Synonyms]
Br-PEG5-OH
CAS_957205-14-0
Bromo-PEG5-alcohol
Reaxys ID: 26537424
14-bromo-3,6,9,12-tetraoxatetradecan-1-ol
3,6,9,12-Tetraoxatetradecan-1-ol, 14-bromo- | [Molecular Formula]
C10H21BrO5 | [MDL Number]
MFCD18252202 | [MOL File]
957205-14-0.mol | [Molecular Weight]
301.17 |
| Hazard Information | Back Directory | [Description]
Bromo-PEG5-alcohol is a PEG linker containing a bromide group and a terminal hydroxyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. | [Uses]
Bromo-PEG5-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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