| Identification | Back Directory | [Name]
Br-PEG3-CH2CO2H | [CAS]
1346502-15-5 | [Synonyms]
Br-PEG3-CH2CO2H
Br-PEG3-CH2COOH
Bromo-PEG3-CH2CO2H
Bromo-PEG3-CH2COOH
2-(2-(2-(2-Bromoethoxy)ethoxy)ethoxy)acetic acid
Acetic acid, 2-[2-[2-(2-bromoethoxy)ethoxy]ethoxy]- | [Molecular Formula]
C8H15BrO5 | [MDL Number]
MFCD30468772 | [MOL File]
1346502-15-5.mol | [Molecular Weight]
271.11 |
| Hazard Information | Back Directory | [Description]
Bromo-PEG3-CH2CO2H is a PEG linker containing a bromide group with a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. | [Uses]
Br-PEG3-CH2COOH (compound 28) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. | [IC 50]
PEGs | [References]
[1] Zha Z, et al. Multidentate (18)F-polypegylated styrylpyridines as imaging agents for Aβ plaques in cerebral amyloid angiopathy (CAA). J Med Chem. 2011 Dec 8;54(23):8085-98. DOI:10.1021/jm2009106 |
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