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169901-27-3

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169901-27-3 Structure

169901-27-3 Structure
IdentificationBack Directory
[Name]

DC-1
[CAS]

169901-27-3
[Synonyms]

DC-1
1H-Indole-2-carboxamide, N-[2-[[(1S)-1-(chloromethyl)-1,2-dihydro-5-hydroxy-3H-benz[e]indol-3-yl]carbonyl]-1H-indol-5-yl]-5-[(3-mercapto-1-oxopropyl)amino]-
[Molecular Formula]

C34H28ClN5O4S
[MDL Number]

MFCD31729541
[MOL File]

169901-27-3.mol
[Molecular Weight]

638.14
Chemical PropertiesBack Directory
[Boiling point ]

940.5±65.0 °C(Predicted)
[density ]

1.523±0.06 g/cm3(Predicted)
[pka]

9.47±0.40(Predicted)
Hazard InformationBack Directory
[Uses]

DC1, an analogue of the minor groove-binding DNA alkylator CC-1065, is a ADC Cytotoxin. DC1 can be used in synthesis of antibody-drug conjugates for the targeted treatment of cancer.
[IC 50]

Duocarmycins
[References]

[1] Kovtun YV, et al. Antibody-drug conjugates designed to eradicate tumors with homogeneous and heterogeneous expression of the target antigen. Cancer Res. 2006 Mar 15;66(6):3214-21. DOI:10.1021/jm201284m
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