| Identification | Back Directory | [Name]
Propargyl-PEG7-NHS ester | [CAS]
2093152-77-1 | [Synonyms]
Propargyl-PEG7-NHS ester
Propargyl-PEG6-CH2CH2COONHS
2,5-Dioxopyrrolidin-1-yl 4,7,10,13,16,19,22-heptaoxapentacos-24-yn-1-oate
4,7,10,13,16,19,22-Heptaoxapentacos-24-ynoic acid, 2,5-dioxo-1-pyrrolidinyl ester | [Molecular Formula]
C22H35NO11 | [MDL Number]
MFCD29041936 | [MOL File]
2093152-77-1.mol | [Molecular Weight]
489.51 |
| Hazard Information | Back Directory | [Description]
Propargyl-PEG7-NHS ester contains a propargyl group and an NHS ester. As an amine reactive reagent, this product can be used for derivatizing peptides, antibodies, amine coated surfaces etc. In the presence of copper catalyst, propargyl group reacts with azide to yield a stable triazole linkage. The PEG units help increase the hydrophilicity of the reagent. | [Uses]
Propargyl-PEG7-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG7-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Propargyl-PEG7-NHS ester is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [IC 50]
Cleavable Linker; PEGs; Alkyl/ether | [References]
[1] Earl F Albone, et al. Eribulin-based antibody-drug conjugates and methods of use. US20170252458A1. |
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