| Identification | Back Directory | [Name]
N-(4-aminobutyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide TFA salt | [CAS]
1799711-25-3 | [Synonyms]
E3 ligase Ligand-Linker Conjugates 16
Cereblon Ligand-Linker Conjugates 6 TFA
Pomalidomide Related Compound 4 Triflate
E3 ligase Ligand-Linker Conjugates 19 (TFA)
N-(4-aminobutyl)-2-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]oxyacetamide
N-(4-aminobutyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide TFA salt
N-(4-Aminobutyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide 2,2,2-trifluoroacetate | [Molecular Formula]
C21H23F3N4O8 | [MDL Number]
MFCD31560484 | [MOL File]
1799711-25-3.mol | [Molecular Weight]
516.43 |
| Hazard Information | Back Directory | [Uses]
Thalidomide-O-amido-C4-NH2 TFA (Cereblon Ligand-Linker Conjugates 6 TFA) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. | [IC 50]
Cereblon | [References]
[1] Zhou B, et al. Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins withPicomolar Cellular Potencies and Capable of Achieving Tumor Regression. J Med Chem. 2017 Mar 24. DOI:10.1021/acs.jmedchem.6b01816
[2] James Bradner, et al. Methods to induce targeted protein degradation through bifunctional molecules. WO 2017024317 A2. |
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