| Identification | Back Directory | [Name]
PROTAC BRD4 Degrader-1 | [CAS]
2133360-00-4 | [Synonyms]
PROTAC BRD4 Degrader-1
Acetamide, 2-[2-[4-[[6-(3,5-dimethyl-4-isoxazolyl)-1,4-dihydro-1-methyl-2-oxo-4-phenyl-3(2H)-quinazolinyl]methyl]-1H-1,2,3-triazol-1-yl]ethoxy]-N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]- | [Molecular Formula]
C40H37N9O8 | [MDL Number]
MFCD34469876 | [MOL File]
2133360-00-4.mol | [Molecular Weight]
771.78 |
| Hazard Information | Back Directory | [Uses]
PROTAC BRD4 Degrader-1 is a PROTAC connected by ligands for Cereblon and BRD4 with an IC50 of 41.8 nM against BRD4 BD1. PROTAC BRD4 Degrader-1 can effectively degrade BRD4 protein and suppress c-Myc expression[1]. | [IC 50]
BRD4 (BD1): 41.8 nM (IC50) | [References]
[1] Zhang F, et al. Discovery of a new class of PROTAC BRD4 degraders based on a dihydroquinazolinone derivative and lenalidomide/pomalidomide.Bioorg Med Chem. 2020 Jan 1;28(1):115228. DOI:10.1016/j.bmc.2019.115228 |
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