| Identification | Back Directory | [Name]
NH-bis(C1-PEG1-Boc) | [CAS]
2171072-53-8 | [Synonyms]
NH-bis(C1-PEG1-Boc)
2-Amino-1,3-bis(t-butoxycarbonylethoxy)propane
di-tert-butyl 3,3'-((2-aminopropane-1,3-diyl)bis(oxy))dipropionate | [Molecular Formula]
C17H33NO6 | [MDL Number]
MFCD32207016 | [MOL File]
2171072-53-8.mol | [Molecular Weight]
347.45 |
| Chemical Properties | Back Directory | [Boiling point ]
419.0±40.0 °C(Predicted) | [density ]
1.043±0.06 g/cm3(Predicted) | [solubility ]
Soluble in DMSO, DCM, DMF | [form ]
Oil | [pka]
6.87±0.10(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Description]
2-Amino-1,3-bis(t-butoxycarbonylethoxy)propane is a PEG linker containing an amino group with two t-butyl esters. The amino group is reactive with carboxylic acids, activated NHS esters. The t-butyl protected carboxyl groups can be deprotected under acidic conditions. | [Uses]
NH-bis(C1-PEG1-Boc) is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
Alkyl/ether | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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