| Identification | Back Directory | [Name]
H2N-PEG6-CH2COOtBu | [CAS]
297162-50-6 | [Synonyms]
NH2-PEG6-C1-Boc
NH2-PEG6-CH2COOtBu
H2N-PEG6-CH2COOtBu
NH2CH2CH2(OCH2CH2)5OCH2CO2-t-Bu
tert-butyl 20-amino-3,6,9,12,15,18-hexaoxaicosanoate | [Molecular Formula]
C18H37NO8 | [MDL Number]
MFCD31656899 | [MOL File]
297162-50-6.mol | [Molecular Weight]
395.488 |
| Chemical Properties | Back Directory | [Boiling point ]
463.4±40.0 °C(Predicted) | [density ]
1.065±0.06 g/cm3(Predicted) | [storage temp. ]
Store at 0-8 °C | [pka]
8.74±0.10(Predicted) | [Appearance]
colorless liquid |
| Hazard Information | Back Directory | [Uses]
NH2-PEG6-C1-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [Biological Activity]
NH2-PEG6-C1-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. | [IC 50]
PEGs | [References]
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
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| Company Name: |
Bide Pharmatech Ltd.
|
| Telephone: |
400-1647117 13681763483 |
| Website: |
https://www.bidepharm.com/ |
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