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2360527-40-6

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2360527-40-6 Structure

2360527-40-6 Structure
IdentificationBack Directory
[Name]

Acetamide, N-(5-aminopentyl)-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-
[CAS]

2360527-40-6
[Synonyms]

Thalidomide-O-amido-C5-NH2
Thalidomide-O-amide-C5-NH2
Acetamide, N-(5-aminopentyl)-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-
[Molecular Formula]

C20H24N4O6
[MDL Number]

MFCD32666632
[MOL File]

2360527-40-6.mol
[Molecular Weight]

416.43
Chemical PropertiesBack Directory
[Boiling point ]

757.3±60.0 °C(Predicted)
[density ]

1.368±0.06 g/cm3(Predicted)
[pka]

10.68±0.40(Predicted)
Hazard InformationBack Directory
[Uses]

Thalidomide-O-amide-C5-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].
[IC 50]

Cereblon
[References]

[1] Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine.?Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11. DOI:10.3389/fcell.2021.629326
[2] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. DOI:10.7554/eLife.57277
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