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303094-67-9

303094-67-9 Structure

303094-67-9 Structure
IdentificationBack Directory
[Name]

1-(4,6-dimethylpyrimidin-2-yl)-3-[2-(trifluoromethyl)phenyl]guanidine
[CAS]

303094-67-9
[Synonyms]

ZINC69391
1-(4,6-dimethylpyrimidin-2-yl)-3-[2-(trifluoromethyl)phenyl]guanidine
[Molecular Formula]

C14H14F3N5
[MDL Number]

MFCD01975775
[MOL File]

303094-67-9.mol
[Molecular Weight]

309.29
Chemical PropertiesBack Directory
[Melting point ]

149-151 °C
[Boiling point ]

404.3±55.0 °C(Predicted)
[density ]

1.35±0.1 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

DMSO : 25 mg/mL (80.83 mM; ultrasonic and warming and heat to 60°C)
[form ]

Solid
[pka]

4.69±0.70(Predicted)
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

ZINC 69391 is a novel specific Rac1 inhibitor, interferring with the interaction of Rac1 with Dock180, a relevant Rac1 activator in glioma invasion, and to reduce Rac1-GTP levels.
[in vivo]

ZINC69391 (25 mg/kg; i.p; daily for 21 days) impairs metastatic lung colonization in a syngeneic animal model[3].

Animal Model:Specific pathogen-free female BALB/c inbred mice (bearing F3II cells)[3]
Dosage:25 mg/kg body weight
Administration:I.p; daily for 21 days
Result:Significantly reduced by about 60% the formation of total metastatic lung colonies.
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