| Identification | Back Directory | [Name]
2-(2-oxobenzo[cd]indol-1(2H)-yl)-N-[2-(trifluoromethyl)phenyl]acetamide | [CAS]
667880-11-7 | [Synonyms]
ZINC00640089
Benz[cd]indole-1(2H)-acetamide, 2-oxo-N-[2-(trifluoromethyl)phenyl]-
2-(2-oxobenzo[cd]indol-1(2H)-yl)-N-[2-(trifluoromethyl)phenyl]acetamide | [Molecular Formula]
C20H13F3N2O2 | [MOL File]
667880-11-7.mol | [Molecular Weight]
370.32 |
| Chemical Properties | Back Directory | [Boiling point ]
589.6±50.0 °C(Predicted) | [density ]
1.455±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
12.82±0.70(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
ZINC00640089 is a specific Lipocalin-2 (LCN2) inhibitor. ZINC00640089 inhibits cell proliferation, cell viability and reduces AKT phosphorylation levels in SUM149 cells. ZINC00640089 has good potential for research in inflammatory breast cancer (IBC)[1]. | [References]
[1] Santiago-Sánchez GS, et al. Targeting Lipocalin-2 in Inflammatory Breast Cancer Cells with Small Interference RNA and Small Molecule Inhibitors. Int J Mol Sci. 2021 Aug 10;22(16):8581. DOI:10.3390/ijms22168581 |
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