| Identification | Back Directory | [Name]
3,4-dihydro-1H-isoquinolin-2-yl-[3-(1H-indol-4-yl)-1,2,4-oxadiazol-5-yl]methanone | [CAS]
1010888-06-8 | [Synonyms]
ZINC12409120
3,4-dihydro-1H-isoquinolin-2-yl-[3-(1H-indol-4-yl)-1,2,4-oxadiazol-5-yl]methanone
Methanone, (3,4-dihydro-2(1H)-isoquinolinyl)[3-(1H-indol-4-yl)-1,2,4-oxadiazol-5-yl]- | [Molecular Formula]
C20H16N4O2 | [MOL File]
1010888-06-8.mol | [Molecular Weight]
344.37 |
| Hazard Information | Back Directory | [Uses]
ZINC12409120 is a high selective ERK inhibitor. ZINC12409120 acts on disrupting FGF23:α-Klotho interaction to inhibit ERK activity with an IC50 of 5.0 μM[1]. | [IC 50]
ERK: 5 μM (IC50) | [References]
[1] Liu SH, et al. Identification of Small-Molecule Inhibitors of Fibroblast Growth Factor 23 Signaling via In Silico Hot Spot Prediction and Molecular Docking to α-Klotho. J Chem Inf Model. 2022 Jul 22. DOI:10.1021/acs.jcim.2c00633 |
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