| Identification | Back Directory | [Name]
PubChem ID: 397887 | [CAS]
308246-57-3 | [Synonyms]
Mj-III-65
LMP744 HCl
PubChem ID: 397887
LMP744 hydrochloride
MJ-III65 hydrochloride
NSC706744 hydrochloride)
LMP744; LMP-744; LMP 744; MJ-III-65; NSC-706744
LMP744 hydrochloride (Synonyms: MJ-III65 hydrochloride
Inhibitor,NSC 706744,LMP744,inhibit,LMP744 hydrochloride,LMP-744,Topoisomerase,LMP-744 hydrochloride,NSC706744,NSC-706744,MJ-III65,LMP 744 | [Molecular Formula]
C24H25ClN2O7 | [MDL Number]
MFCD31813789 | [MOL File]
308246-57-3.mol | [Molecular Weight]
488.92 |
| Chemical Properties | Back Directory | [Melting point ]
284-288 °C | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 5.56 mg/mL (11.37 mM) | [form ]
Solid | [color ]
Light brown to brown |
| Hazard Information | Back Directory | [Uses]
LMP744 hydrochloride (MJ-III65 hydrochloride) is a DNA intercalator and Topoisomerase I (Top1) inhibitor with antitumor activity[1]. | [in vivo]
LMP744 (MJ-III-65) (10-50 mg/kg) administered i.v. push once a week for 4 weeks in nude mice moderately actives against human A253 and FaDu tumor xenografts without significant toxicity[1]. | Animal Model: | Athymic nude mice (nu/nu, female, 20-25 g, 8-12 weeks old) transplanted with A253 and FaDu human head and neck xenografts[1]. | | Dosage: | 10, 25, or 50 mg/kg/week, 4 weeks | | Administration: | I.V. push via tail vein | | Result: | Moderately actived against human A253 and FaDu tumor xenografts without significant toxicity. |
| [IC 50]
Top1 | [storage]
Store at -20°C | [References]
[1] Antony S, et al. Cellular topoisomerase I inhibition and antiproliferative activity by MJ-III-65 (NSC 706744), an indenoisoquinoline topoisomerase I poison. Mol Pharmacol. 2005 Feb;67(2):523-30. DOI:10.1124/mol.104.003889
[2] Antony S, et al. Bisindenoisoquinoline bis-1,3-{( 5,6-dihydro-5,11-diketo-11H-indeno [1,2-c]isoquinoline)-6-propylamino}propane bis(trifluoroacetate) (NSC 727357), a DNA intercalator and topoisomerase inhibitor with antitumor activity. Mol Pharmacol. 2006 DOI:10.1124/mol.106.024372 |
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