13,14-Dihydro-15-keto prostaglandin E2
- CAS No.
- 363-23-5
- Chemical Name:
- 13,14-Dihydro-15-keto prostaglandin E2
- Synonyms
- PGEM;13,14-Dihydro-15-keto-PGE2;CUJMXIQZWPZMNQ-XYYGWQPLSA-N;15-keto-13,14-dihydroprostaglandine2;13,14-dihydro-15-oxo-prostaglandin E2;13,14-Dihydro-15-keto prostaglandin E2;13,14-Dihydro-15-ketoprostaglandinE2 solution;9,15-DIOXO-11ALPHA-HYDROXY-PROST-5Z-EN-1-OIC ACID;(5Z)-11α-Hydroxy-9,15-dioxoprosta-5-ene-1-oic acid;(5Z,11α)-11-Hydroxy-9,15-dioxoprost-5-en-1-oic acid
- CBNumber:
- CB8349316
- Molecular Formula:
- C20H32O5
- Molecular Weight:
- 352.47
- MDL Number:
- MFCD00135217
- MOL File:
- 363-23-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H312-H315-H319-H332-H335-H351 | |||||||||
| Precautionary statements | P261-P280-P305+P351+P338 | |||||||||
| Hazard Codes | F,Xn,Xi | |||||||||
| Risk Statements | 11-20/21/22-36/37/38-67-66-36 | |||||||||
| Safety Statements | 16-26-36 | |||||||||
| RIDADR | UN 1231 3/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| NFPA 704 |
|
13,14-Dihydro-15-keto prostaglandin E2 price More Price(7)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 14650 | 13,14-dihydro-15-keto Prostaglandin E2 ≥95% | 363-23-5 | 1mg | $76 | 2026-04-30 | Buy |
| Cayman Chemical | 14650 | 13,14-dihydro-15-keto Prostaglandin E2 ≥95% | 363-23-5 | 5mg | $343 | 2026-04-30 | Buy |
| Cayman Chemical | 14650 | 13,14-dihydro-15-keto Prostaglandin E2 ≥95% | 363-23-5 | 10mg | $646 | 2026-04-30 | Buy |
| aablocks | AA00C09Y | 13,14-dihydro-15-keto Prostaglandin E2 ≥95% | 363-23-5 | 1mg | $76 | 2026-05-28 | Buy |
| aablocks | AA00C09Y | 13,14-dihydro-15-keto Prostaglandin E2 ≥95% | 363-23-5 | 5mg | $343 | 2026-05-28 | Buy |
13,14-Dihydro-15-keto prostaglandin E2 Chemical Properties, Uses, Production
Description
13,14-dihydro-15-keto Prostaglandin E2 (13,14-dihydro-15-keto PGE2) is a metabolite of PGE2 and the primary PGE2 metabolite in plasma. It is formed from PGE2 via a 15-keto PGE2 intermediate by 15-oxo-PG Δ13 reductase. Unlike PGE2, 13,14-dihydro-15-keto PGE2 does not bind effectively to the PGE2 receptors EP2 and EP4 expressed in CHO cells (Kis = 12 and 57 μM, respectively) or induce adenylate cyclase activity in the same cells (EC50s = >18 and >38 μM, respectively). Levels of 13,14-dihydro-15-keto PGE2 are increased in the plasma of women in the third trimester of pregnancy and in women during and immediately after labor and delivery. Levels of 13,14-dihydro-15-keto PGE2 levels are decreased in tumor tissue compared to adjacent non-cancerous tissue isolated from patients with non-small cell lung cancer (NSCLC).
Uses
13,14-Dihydro-15-ketoPGE2 is a primary metabolite of PGE2 in plasma.
Definition
ChEBI: The 13,14-dihydro derivative of 15-oxo-prostaglandin E2.
References
[1] P. HUSSLEIN H. S. Concentration of 13,14-dihydro-15-keto-prostaglandin E2 in the maternal peripheral plasma during labour of spontaneous onset[J]. Bjog-An International Journal of Obstetrics and Gynaecology, 1984, 91 3: 228-231. DOI: 10.1111/j.1471-0528.1984.tb04757.x
[2] DUNCAN HUGHES. NAD+-dependent 15-hydroxyprostaglandin dehydrogenase regulates levels of bioactive lipids in non-small cell lung cancer.[J]. Cancer prevention research (Philadelphia, Pa.), 2008, 1 4: 241-249. DOI: 10.1158/1940-6207.capr-08-0055
[3] JOVANA MARIC PHD , PHD Gerd G M Nerea Ferreirós PhD, PHD Danielle F M, et al. Cytokine-induced endogenous production of prostaglandin D2 is essential for human group 2 innate lymphoid cell activation[J]. Journal of Allergy and Clinical Immunology, 2019, 143 6: Pages 2202-2214.e5. DOI: 10.1016/j.jaci.2018.10.069
[4] M. HAMBERG B S. On the Metabolism of Prostaglandins E1 and E2 in Man[J]. Journal of Biological Chemistry, 1971, 246 1: 6713-6721. DOI: 10.1016/s0021-9258(19)45905-x
[5] N. NISHIGAKI A I M Negishi. Two Gs-coupled prostaglandin E receptor subtypes, EP2 and EP4, differ in desensitization and sensitivity to the metabolic inactivation of the agonist.[J]. Molecular Pharmacology, 1996, 146 1: 1031-1037. DOI: 10.1254/fpj.108.supplement_65
[6] DAVID MERIWETHER. Apolipoprotein A-I mimetics mitigate intestinal inflammation in COX2-dependent inflammatory bowel disease model.[J]. Journal of Clinical Investigation, 2019, 129 9: 3670-3685. DOI: 10.1172/jci123700
13,14-Dihydro-15-keto prostaglandin E2 Preparation Products And Raw materials
Raw materials
Preparation Products
13,14-Dihydro-15-keto prostaglandin E2 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 400-920-5774 | sales@glpbio.cn | China | 6705 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
| Guangzhou Younan Technology Co., Ltd | 020-82000279 18988941452 | YN_research@163.com | China | 2984 | 58 |
| Hubei Kele Fine Chemical Co., Ltd | 027-59101668 19945030958 | 2223443625@qq.com | China | 7998 | 58 |
| amyjet | 4006800868;027-59626688 18771149750 | sales@amyjet.com | China | 2909 | 58 |
| Shanghai Aladdin Biochemical Technology Co.,Ltd. | 6206333 13167063860 | anhua.mao@aladdin-e.com | China | 43553 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
| Chengdu Peter-like Biotechnology Co., Ltd. | 028-81700200 13308200041 | 2851167782@qq.com | China | 10763 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +86-18327326525 | masar@topule.com | China | 8433 | 58 |
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