2-Bromo-5-(trifluoromethyl)benzoic acid
- CAS No.
- 1483-56-3
- Chemical Name:
- 2-Bromo-5-(trifluoromethyl)benzoic acid
- Synonyms
- 2-Bromo-5-(trifluoromethyl)benzoic acid;Benzoic acid, 2-bromo-5-(trifluoromethyl)-;4-Bromo-3-carboxybenzotrifluoride, 6-Bromo-alpha,alpha,alpha-trifluoro-m-toluic acid
- CBNumber:
- CB01263769
- Molecular Formula:
- C8H4BrF3O2
- Molecular Weight:
- 269.02
- MDL Number:
- MFCD06208253
- MOL File:
- 1483-56-3.mol
- MSDS File:
- SDS
| Melting point | 116-117℃ |
|---|---|
| Boiling point | 301.0±42.0 °C(Predicted) |
| Density | 1.773 |
| storage temp. | Sealed in dry,Room Temperature |
| pka | 2.42±0.10(Predicted) |
| form | Solid |
| Appearance | White to off-white Solid |
| Water Solubility | Slightly soluble in water. |
| InChI | InChI=1S/C8H4BrF3O2/c9-6-2-1-4(8(10,11)12)3-5(6)7(13)14/h1-3H,(H,13,14) |
| InChIKey | REBQGRPKXYIJDC-UHFFFAOYSA-N |
| SMILES | C(O)(=O)C1=CC(C(F)(F)F)=CC=C1Br |
| CAS DataBase Reference | 1483-56-3 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a |
| HazardClass | IRRITANT |
| HS Code | 2916399090 |
2-Bromo-5-(trifluoromethyl)benzoic acid price More Price(53)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | PC48364 | 2-Bromo-5-(trifluoromethyl)benzoic acid >98% | 1483-56-3 | 5g | $21 | 2026-06-04 | Buy |
| Apolloscientific | PC48364 | 2-Bromo-5-(trifluoromethyl)benzoic acid >98% | 1483-56-3 | 25g | $74 | 2026-06-04 | Buy |
| Apolloscientific | PC48364 | 2-Bromo-5-(trifluoromethyl)benzoic acid >98% | 1483-56-3 | 100g | $275 | 2026-06-04 | Buy |
| Apolloscientific | PC48364 | 2-Bromo-5-(trifluoromethyl)benzoic acid >98% | 1483-56-3 | 500g | $959 | 2026-06-04 | Buy |
| Activate Scientific | AS38486 | 2-Bromo-5-(trifluoromethyl)benzoic acid 97% | 1483-56-3 | 1g | $22 | 2026-06-04 | Buy |
2-Bromo-5-(trifluoromethyl)benzoic acid Chemical Properties, Uses, Production
Chemical Properties
off-white powder
Uses
2-Bromo-5-(trifluoromethyl)benzoic acid is used as an organic synthesis reagent or pharmaceutical intermediate compound.
Synthesis
2,2,6,6-tetramethylhexahydropiperidine (22.5 ml, 133.4 mmol) was added to a solution of n-BuLi (26.7 ml of a 2.5 M solution in tetrahydrofuran (THF), 66.7 mmol) in THF (130 ml) at -78 C. The mixture was stirred at -78 C for 30 min and then carefully lowered to -100 C using liquid nitrogen. Pure 1-bromo-4-(trifluoromethyl)benzene (15 g, 66.7 mmol) was added. The mixture was kept at -100 C for 6 hours and poured onto freshly crushed dry ice. The resulting mixture was stirred at room temperature for 16 hours. The residual solvent was removed by evaporation. Water (150 ml) was added and the mixture was extracted (50 ml three times) with ether. The aqueous layer was acidified using concentrated hydrochloric acid (HCl) and extracted with dichloromethane (50 ml three times). The combined organic layers were washed with saturated sodium chloride (75 ml), dried over magnesium sulfate (MgSO4), filtered and concentrated to yield 2-bromo-5-trifluoromethylbenzoic acid as a white solid (5.41 g).1H NMR (300 MHz, chloroform-D) ppm 7.7 (dd, J = 8.4, 2.3 Hz, 1H) 7.9 (d, J = 8.4 Hz, 1H) 8.3 (d, J = 2.0 Hz, 1H); MS (ES+) calculated value: 267.93, measured value: 266.7 (M-1).
2-Bromo-5-(trifluoromethyl)benzoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Zhuhai Aobokai Biomedical Technology Co., Ltd. | 400-0628126 | sales-team@aobchem.com.cn | China | 49995 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
| Shanghai Harvest Chemical Industrial Co., Ltd. | 15721252604 17321035817 | sales@harvest-chem.com | China | 2829 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Shanghai Sphchem Co., Ltd. | 021-56491756 13512199871 | 2819742715@qq.com | China | 3994 | 55 |
View Latest Price from 2-Bromo-5-(trifluoromethyl)benzoic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-09 | 2-BROMO-5-(TRIFLUOROMETHYL)BENZOIC ACID
1483-56-3
|
$9.80 | 1g | ≥99% | 100kg | Career Henan Chemical Co | |
 |
2019-12-19 | 2-BROMO-5-(TRIFLUOROMETHYL)BENZOIC ACID
1483-56-3
|
$1.00 | 1KG | 98 | 10t | Career Henan Chemical Co |
-
- 2-BROMO-5-(TRIFLUOROMETHYL)BENZOIC ACID
1483-56-3
- $9.80
- ≥99%
- Career Henan Chemical Co
-
- 2-BROMO-5-(TRIFLUOROMETHYL)BENZOIC ACID
1483-56-3
- $1.00
- 98
- Career Henan Chemical Co
