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4-(Methylsulfonyl)phenol

4-(Methylsulfonyl)phenol Structure
4-(Methylsulfonyl)phenol structure
CAS No.
14763-60-1
Chemical Name:
4-(Methylsulfonyl)phenol
Synonyms
4-(METHYLSULFONYL)PHENOL;4-METHYLSULPHONYLPHENOL;4-Hydroxyphenyl methyl sulfone;4-Mesylphenol;4-Methylsulfonylphen;p-Methylsulphonylphenol;4-(methylsulfonyl)-pheno;4-METHANESULFONYL-PHENOL;p-(Methylsulfonyl)phenol;p-(methylsulfonyl)-pheno
CBNumber:
CB0135245
Molecular Formula:
C7H8O3S
Molecular Weight:
172.2
MDL Number:
MFCD00047806
MOL File:
14763-60-1.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-27 17:18:21
Product description Number Pack Size Price
4-Hydroxyphenyl Methyl Sulfone >98.0%(GC) H1367 5g $53
4-Hydroxyphenyl Methyl Sulfone >98.0%(GC) H1367 25g $176
4-Methanesulfonylphenol Asreported 283331 10g $333
4-Methanesulfonylphenol Asreported 283331 25g $460
4-Methanesulfonylphenol Asreported 283331 50g $602
More product size
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4-(Methylsulfonyl)phenol Properties

Melting point 90-95 °C
Boiling point 272.52°C (rough estimate)
Density 1.3692 (rough estimate)
refractive index 1.5151 (estimate)
RTECS SM1530000
storage temp. Inert atmosphere,Room Temperature
solubility DMSO, Methanol
form Powder
pka pK1:7.83 (25°C)
color Tan to pink-brown
Water Solubility slight
BRN 1866322
LogP 0.886 (est)
CAS DataBase Reference 14763-60-1(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII F7BIF7ZQJ9
NIST Chemistry Reference 4-(Methylsulfonyl)phenol(14763-60-1)

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H303-H315-H335-H319
Precautionary statements  P280g-P264-P280-P305+P351+P338+P337+P313-P305+P351+P338
Hazard Codes  Xi
Risk Statements  36
Safety Statements  24/25-26
WGK Germany  3
Hazard Note  Irritant
HS Code  29309090
NFPA 704
0
1 0

4-(Methylsulfonyl)phenol price More Price(62)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical H1367 4-Hydroxyphenyl Methyl Sulfone >98.0%(GC) 14763-60-1 5g $53 2026-04-30 Buy
TCI Chemical H1367 4-Hydroxyphenyl Methyl Sulfone >98.0%(GC) 14763-60-1 25g $176 2026-04-30 Buy
Usbiological 283331 4-Methanesulfonylphenol Asreported 14763-60-1 10g $333 2026-06-03 Buy
Usbiological 283331 4-Methanesulfonylphenol Asreported 14763-60-1 25g $460 2026-06-03 Buy
Usbiological 283331 4-Methanesulfonylphenol Asreported 14763-60-1 50g $602 2026-06-03 Buy
Product number Packaging Price Buy
H1367 5g $53 Buy
H1367 25g $176 Buy
283331 10g $333 Buy
283331 25g $460 Buy
283331 50g $602 Buy

4-(Methylsulfonyl)phenol Chemical Properties,Uses,Production

Chemical Properties

Tan to pink-brown powder

Uses

4-(Methylsulfonyl)phenol is a reagent in the synthesis of pyrazolo[3,4-d]pyrimidine derivatives as GPR119 agonists. Also a reagent in the synthesis of novel 2-(pyridine-2-yl)-1H-benzimidazole derivatives as potent glucokinase activators.

Reactions

The reaction of 4-(methylsulfonyl)phenol (17.2 g, 100.0 mmol) with p-Toluenesulfonic anhydride as outlined in the general procedure provided 4-(methylsulfonyl)phenyl 4-methylbenzenesulfonate (26.1 g, 81%).

Synthesis

4-(Methylthio)phenol

1073-72-9

4-(Methylsulfonyl)phenol

14763-60-1

Step 2. Synthesis of 4-(methylsulfonyl)phenol Oxone (0.99 g, 6.5 mmol) was added batchwise to a solution of 4-(methylthio)phenol (0.50 g, 3.2 mmol) in ethanol (10.0 mL). Subsequently, water (10.0 mL) was added at room temperature. The reaction mixture was stirred for 18 h, after which it was partitioned between ethyl acetate and water. The combined organic layers were washed with brine, dried over magnesium sulfate, and concentrated under vacuum to afford 4-(methylsulfonyl)phenol as a semi-solid (0.60 g, 96% yield). LCMS calculated value C7H9O3S ([M + H]+): m/z = 173.0; measured value: 173.0.

References

[1] Patent: WO2015/164480, 2015, A1. Location in patent: Page/Page column 106; 107
[2] Journal of Organic Chemistry, 2003, vol. 68, # 13, p. 5388 - 5391
[3] Green Chemistry, 2014, vol. 16, # 4, p. 2190 - 2196
[4] Journal of the Indian Chemical Society, 1982, vol. 59, # 1, p. 52 - 54
[5] Patent: EP1598349, 2005, A1. Location in patent: Page/Page column 127

4-(Methylsulfonyl)phenol synthesis

1073-72-9
14763-60-1
Synthesis of 4-(Methylsulfonyl)phenol from 4-(Methylthio)phenol

4-(Methylsulfonyl)phenol Preparation Products And Raw materials

Raw materials

Hydrogen peroxide Acetyl chloride Chloroform Carbon tetrachloride Ethyl acetate
Hydrochloric acid Acetic acid Sodium periodate Sodium hydroxide 4-(Methylthio)phenol
Magnesium sulfate

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Preparation Products

2-BROMO-4-(METHYLSULFONYL)PHENOL 1-(2-bromoethoxy)-4-(methylsulfonyl)benzene

4-(Methylsulfonyl)phenol Suppliers

Global( 172)Suppliers
Supplier Tel Email Country ProdList Advantage
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652 info@fdachem.com China 20120 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806 sales@capot.com China 29640 60
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
Wuhan Chemwish Technology Co., Ltd 		027-67849912 sales@chemwish.com CHINA 10821 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49979 58
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29792 58
Hefei TNJ Chemical Industry Co.,Ltd. 		+86-0551-65418671 +8618949823763 sales@tnjchem.com China 34563 58
Hebei Zhanyao Biotechnology Co. Ltd 		15369953316 +8615369953316 admin@zhanyaobio.com China 2123 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1059@dideu.com China 29094 58
Hefei Hirisun Pharmatech Co., Ltd 		+8615056975894 shawn@hirisunpharm.com CHINA 9911 58
Supplier Advantage
Henan Fengda Chemical Co., Ltd 		58
Capot Chemical Co.,Ltd. 		60
Alchem Pharmtech,Inc. 		58
Wuhan Chemwish Technology Co., Ltd 		58
CONIER CHEM AND PHARMA LIMITED 		58
career henan chemical co 		58
Hefei TNJ Chemical Industry Co.,Ltd. 		58
Hebei Zhanyao Biotechnology Co. Ltd 		58
Dideu Industries Group Limited 		58
Hefei Hirisun Pharmatech Co., Ltd 		58

View Lastest Price from 4-(Methylsulfonyl)phenol manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-(Methylsulfonyl)phenol pictures 2026-07-09 4-(Methylsulfonyl)phenol
14763-60-1
 $1.00-100.00 1KG 99% Henan Fengda Chemical Co., Ltd
4-Methylsulfonylphenol pictures 2023-04-12 4-Methylsulfonylphenol
14763-60-1
 $15.00 1Kg/Bag above99% Wuhan Dujiang Industrial Co., Ltd.
4-Methylsulfonylphenol pictures 2021-10-21 4-Methylsulfonylphenol
14763-60-1
 $10.00 1KG 99% 20 tons Hebei Zhanyao Biotechnology Co. Ltd

4-(Methylsulfonyl)phenol Spectrum

4-(Methylsulfonyl)phenol(14763-60-1)1HNMR

14763-60-1(4-(Methylsulfonyl)phenol)Related Search:

Bis(4-hydroxyphenyl) Sulfone 4,4'-BIS(3-AMINOPHENOXY)DIPHENYL SULFONE BIS(4-HYDROXY-3,5-DIMETHYLPHENYL) SULFONE 4,4'-Sulphonylbis(2,6-dibromophenol) Bis[4-(4-aminophenoxy)phenyl]sulfone
4-METHOXYPHENYLMETHYLSULFONE 4-(Methylsulfonyl)phenol REACTIVE VIOLET 5 3,3'-Diamino-4,4'-dihydroxydiphenyl sulfone 4-(methylsulphonyl)-2-nitrophenol
3-AMINO-4-METHOXYPHENYL ETHYL SULFONE 2-AMINO-4-(ETHYLSULFONYL)PHENOL 2-PROPANONE, 1-[(4-METHOXYPHENYL)SULFONYL]- P-FLUOROPHENYL-P-METHOXYPHENYL SULFONE ETHYL 2-[(4-METHOXYPHENYL)SULFONYL]ACETATE
4-((4-[(3-CHLORO-2,2-DIMETHYLPROPANOYL)OXY]-3,5-DIMETHYLPHENYL)SULFONYL)-2,6-DIMETHYLPHENYL 3-CHLORO-2,2-DIMETHYLPROPANOATE AKOS BBS-00002840

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4-(METHYLSULFONYL)PHENOL 4-METHYLSULPHONYLPHENOL 4-METHANESULFONYL-PHENOL 4-(methylsulfonyl)-pheno 4-hydroxyphenylmethylsulfone p-(methylsulfonyl)-pheno p-(Methylsulfonyl)phenol Phenol, 4-(methylsulfonyl)- Phenol, p-(methylsulfonyl)- p-Hydroxyphenyl methyl sulfone p-hydroxyphenylmethylsulfone 4-METHANESULPHONYLPHENOL 4-METHYLSULPHONYLPHENOL 95% p-Methylsulphonylphenol 4-Methylsulphonylphenol,95% 4-Mesylphenol 4-Methylsulfonylphen 4-Methylsulphonylphenol, 95% 2.5GR 4-HydroxyphenylMethylSulfone> 4-Methylsulfonylphenol ISO 9001：2015 REACH 4-Hydroxyphenyl methyl sulfone 4-(Methylsulfonyl)phenol (ACI) 14763-60-1