4-(Methylsulfonyl)phenol
- CAS No.
- 14763-60-1
- Chemical Name:
- 4-(Methylsulfonyl)phenol
- Synonyms
- 4-(METHYLSULFONYL)PHENOL;4-METHYLSULPHONYLPHENOL;4-Hydroxyphenyl methyl sulfone;4-Mesylphenol;4-Methylsulfonylphen;p-Methylsulphonylphenol;4-(methylsulfonyl)-pheno;4-METHANESULFONYL-PHENOL;p-(Methylsulfonyl)phenol;p-(methylsulfonyl)-pheno
- CBNumber:
- CB0135245
- Molecular Formula:
- C7H8O3S
- Molecular Weight:
- 172.2
- MDL Number:
- MFCD00047806
- MOL File:
- 14763-60-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 90-95 °C |
|---|---|
| Boiling point | 272.52°C (rough estimate) |
| Density | 1.3692 (rough estimate) |
| refractive index | 1.5151 (estimate) |
| RTECS | SM1530000 |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | DMSO, Methanol |
| form | Powder |
| pka | pK1:7.83 (25°C) |
| color | Tan to pink-brown |
| Water Solubility | slight |
| BRN | 1866322 |
| LogP | 0.886 (est) |
| CAS DataBase Reference | 14763-60-1(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | F7BIF7ZQJ9 |
| NIST Chemistry Reference | 4-(Methylsulfonyl)phenol(14763-60-1) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H303-H315-H335-H319 | |||||||||
| Precautionary statements | P280g-P264-P280-P305+P351+P338+P337+P313-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36 | |||||||||
| Safety Statements | 24/25-26 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Irritant | |||||||||
| HS Code | 29309090 | |||||||||
| NFPA 704 |
|
4-(Methylsulfonyl)phenol price More Price(59)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | H1367 | 4-Hydroxyphenyl Methyl Sulfone >98.0%(GC) | 14763-60-1 | 5g | $53 | 2026-04-30 | Buy |
| TCI Chemical | H1367 | 4-Hydroxyphenyl Methyl Sulfone >98.0%(GC) | 14763-60-1 | 25g | $176 | 2026-04-30 | Buy |
| Usbiological | 283331 | 4-Methanesulfonylphenol Asreported | 14763-60-1 | 10g | $333 | 2026-06-03 | Buy |
| Usbiological | 283331 | 4-Methanesulfonylphenol Asreported | 14763-60-1 | 25g | $460 | 2026-06-03 | Buy |
| Usbiological | 283331 | 4-Methanesulfonylphenol Asreported | 14763-60-1 | 50g | $602 | 2026-06-03 | Buy |
4-(Methylsulfonyl)phenol Chemical Properties, Uses, Production
Chemical Properties
Tan to pink-brown powder
Uses
4-(Methylsulfonyl)phenol is a reagent in the synthesis of pyrazolo[3,4-d]pyrimidine derivatives as GPR119 agonists. Also a reagent in the synthesis of novel 2-(pyridine-2-yl)-1H-benzimidazole derivatives as potent glucokinase activators.
Reactions
The reaction of 4-(methylsulfonyl)phenol (17.2 g, 100.0 mmol) with p-Toluenesulfonic anhydride as outlined in the general procedure provided 4-(methylsulfonyl)phenyl 4-methylbenzenesulfonate (26.1 g, 81%).
Synthesis
1073-72-9
14763-60-1
Step 2. Synthesis of 4-(methylsulfonyl)phenol Oxone (0.99 g, 6.5 mmol) was added batchwise to a solution of 4-(methylthio)phenol (0.50 g, 3.2 mmol) in ethanol (10.0 mL). Subsequently, water (10.0 mL) was added at room temperature. The reaction mixture was stirred for 18 h, after which it was partitioned between ethyl acetate and water. The combined organic layers were washed with brine, dried over magnesium sulfate, and concentrated under vacuum to afford 4-(methylsulfonyl)phenol as a semi-solid (0.60 g, 96% yield). LCMS calculated value C7H9O3S ([M + H]+): m/z = 173.0; measured value: 173.0.
References
[1] Patent: WO2015/164480, 2015, A1. Location in patent: Page/Page column 106; 107
[2] Journal of Organic Chemistry, 2003, vol. 68, # 13, p. 5388 - 5391
[3] Green Chemistry, 2014, vol. 16, # 4, p. 2190 - 2196
[4] Journal of the Indian Chemical Society, 1982, vol. 59, # 1, p. 52 - 54
[5] Patent: EP1598349, 2005, A1. Location in patent: Page/Page column 127
4-(Methylsulfonyl)phenol Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Ningbo Chemrio Chemtech Co,.Ltd. | 0574-27891269 18667892864 | frank.xiaodong@chemriotech.com | China | 3953 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Shanghai Sinch Parmaceuticals Tech. Co. Ltd. | +86-21-54098501 | sales@sinch.com.cn | China | 11592 | 64 |
| ShengXiong Biological Technology Development Co., Ltd. | 86-021-64960112 13774219177 | alpha9196@gmail.com | China | 52 | 65 |
View Latest Price from 4-(Methylsulfonyl)phenol manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-02 | 4-(Methylsulfonyl)phenol
14763-60-1
|
$1.00-100.00 | 1KG | 99% | Henan Fengda Chemical Co., Ltd | ||
 |
2023-04-12 | 4-Methylsulfonylphenol
14763-60-1
|
$15.00 | 1Kg/Bag | above99% | Wuhan Dujiang Industrial Co., Ltd. | ||
 |
2021-10-21 | 4-Methylsulfonylphenol
14763-60-1
|
$10.00 | 1KG | 99% | 20 tons | Hebei Zhanyao Biotechnology Co. Ltd |
-
- 4-(Methylsulfonyl)phenol
14763-60-1
- $1.00-100.00
- 99%
- Henan Fengda Chemical Co., Ltd
-
- 4-Methylsulfonylphenol
14763-60-1
- $15.00
- above99%
- Wuhan Dujiang Industrial Co., Ltd.
-
- 4-Methylsulfonylphenol
14763-60-1
- $10.00
- 99%
- Hebei Zhanyao Biotechnology Co. Ltd
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