6-(1H-Pyrazol-1-yl)nicotinic acid
- CAS No.
- 253315-22-9
- Chemical Name:
- 6-(1H-Pyrazol-1-yl)nicotinic acid
- Synonyms
- CAS:253315-22-9;6-(1-Pyrazolyl)nicotinic Acid;6-Pyrazol-1-yl-nicotinic acid;6-(1H-Pyrazol-1-yl)nicotinic acid;6-(1H-Pyrazol-1-yl)nicotinic acid ,97%;6-pyrazol-1-ylpyridine-3-carboxylic acid;6-(1H-Pyrazol-1-yl)pyridine-3-carboxylic acid;6-(1H-Pyrazol-1-yl)-pyridin-3-carboxylic acid;3-Pyridinecarboxylic acid, 6-(1H-pyrazol-1-yl)-
- CBNumber:
- CB01481996
- Molecular Formula:
- C9H7N3O2
- Molecular Weight:
- 189.17
- MDL Number:
- MFCD00140749
- MOL File:
- 253315-22-9.mol
- MSDS File:
- SDS
| Melting point | 272-274℃ |
|---|---|
| Boiling point | 394.6±27.0 °C(Predicted) |
| Density | 1.39±0.1 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| form | solid |
| pka | 3.28±0.10(Predicted) |
| color | White to off-white |
| CAS DataBase Reference | 253315-22-9 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36/37/39 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29333990 | |||||||||
| NFPA 704 |
|
6-(1H-Pyrazol-1-yl)nicotinic acid price More Price(31)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | OR938164 | 6-(1H-Pyrazol-1-yl)nicotinic acid 97% | 253315-22-9 | 1g | $97 | 2026-06-04 | Buy |
| Apolloscientific | OR938164 | 6-(1H-Pyrazol-1-yl)nicotinic acid 97% | 253315-22-9 | 5g | $263 | 2026-06-04 | Buy |
| Synthonix | P51143 | 6-(1H-Pyrazol-1-yl)nicotinic acid 97% | 253315-22-9 | 250mg | $25 | 2026-05-06 | Buy |
| Synthonix | P51143 | 6-(1H-Pyrazol-1-yl)nicotinic acid 97% | 253315-22-9 | 1g | $31 | 2026-05-06 | Buy |
| Synthonix | P51143 | 6-(1H-Pyrazol-1-yl)nicotinic acid 97% | 253315-22-9 | 5g | $80 | 2026-05-06 | Buy |
6-(1H-Pyrazol-1-yl)nicotinic acid Chemical Properties, Uses, Production
Chemical Properties
White solid
Uses
6-(1H-Pyrazol-1-yl)nicotinic acid is used as a ligand in the synthesis of MOF materials.
Synthesis
1428929-49-0
253315-22-9
Compound 1 (CAS: 1428929-49-0, 8.66 g, 40.43 mmol, 1.0 eq.) was dissolved in anhydrous ethanol (80 mL), followed by slow addition of 3 M aqueous sodium hydroxide solution (40.40 mL, 121.3 mmol, 3.0 eq.). The reaction mixture was stirred overnight at room temperature. Upon completion of the reaction, the solvent was removed by reduced pressure distillation and the residue was dissolved in deionized water (60 mL). The aqueous phase was extracted twice with ether (40 mL × 2) to remove organic impurities. Subsequently, the pH of the aqueous phase was adjusted to 3 with 2 M aqueous hydrochloric acid, at which time a white solid precipitated. The white solid was collected by filtration and dried to give 6-(1H-pyrazol-1-yl)nicotinic acid (7.42 g, 97% yield). The structure of the product was confirmed by 1H NMR (400 MHz, DMSO-d6): δ 6.65 (dd, J = 2.7, 1.6 Hz, 1H, Ar-H), 7.92 (dd, J = 1.6, 0.8 Hz, 1H, Ar-H), 8.04 (dd, J = 8.6, 0.8 Hz, 1H, Ar-H), 8.44 (dd, J = 8.6 , 2.3 Hz, 1H, Ar-H), 8.70 (dd, J = 2.7, 0.8 Hz, 1H, Ar-H), 8.96 (dd, J = 2.3, 0.8 Hz, 1H, Ar-H), 13.44 (s, 1H, COOH).
References
[1] European Journal of Medicinal Chemistry, 2018, vol. 154, p. 68 - 90
[2] Patent: WO2014/85210, 2014, A1. Location in patent: Page/Page column 40
6-(1H-Pyrazol-1-yl)nicotinic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Nanjing Habo Medical Technology Co., Ltd. | 13376080562 13376090521 | sales@habotech.com | China | 724 | 60 |
| Shanghai Longsheng chemical Co.,Ltd. | 58099637 13585536065 | sales@shlschem.com | China | 9880 | 59 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16306 | 64 |
| Hunan Hui Bai Shi Biotechnology Co., Ltd. | 0731-85526065 13308475853 | ivy@hnhbsj.com | China | 7236 | 62 |
| Nanjing Vital Chemical Co., Ltd. | Please Send Email 18652950785 | chemweiao@163.com | China | 4368 | 65 |
| Acorn PharmaTech Co., Ltd. | 025-58395930 | sales@acornpharma.com | China | 982 | 60 |
View Latest Price from 6-(1H-Pyrazol-1-yl)nicotinic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2026-07-15 | 6-(1H-Pyrazol-1-yl)nicotinic acid
253315-22-9
|
1KG | 98% | 1000kg | Shaanxi Dideu New Materials Co. Ltd |
-
- 6-(1H-Pyrazol-1-yl)nicotinic acid
253315-22-9
- $0.00
- 98%
- Shaanxi Dideu New Materials Co. Ltd
