Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>ATM Inhibitor-7

ATM Inhibitor-7

ATM Inhibitor-7 Structure
ATM Inhibitor-7 structure
CAS No.
3033712-80-7
Chemical Name:
ATM Inhibitor-7
Synonyms
ATM Inhibitor-7;1-Propanamine, N,N-dimethyl-3-[[5-[1-[(1R)-1-phenylethyl]-1H-1,2,3-triazolo[4,5-c]quinolin-8-yl]-2-pyridinyl]oxy]-
CBNumber:
CB014907829
Molecular Formula:
C27H28N6O
Molecular Weight:
452.55
MDL Number:
MOL File:
3033712-80-7.mol
MSDS File:
SDS
Last updated:2025-08-21 14:05:29
Request For Quotation

ATM Inhibitor-7 Properties

Boiling point 658.733±55.00 °C(Press: 760.00 Torr)(predicted)
Density 1.228±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
solubility DMF: 10 mg/ml
DMSO: 10 mg/ml
Ethanol: 10 mg/mlPBS (pH 7.2): Slightly

ATM Inhibitor-7 price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 39183 A011 ≥95% 3033712-80-7 1mg $63 2026-04-30 Buy
Cayman Chemical 39183 A011 ≥95% 3033712-80-7 5mg $294 2026-04-30 Buy
ChemScene CS-0835118 ATM Inhibitor-7 3033712-80-7 1mg $212 2026-06-04 Buy
ChemScene CS-0835118 ATM Inhibitor-7 3033712-80-7 5mg $636 2026-06-04 Buy
aablocks AA02AG23 A011 ≥95% 3033712-80-7 1mg $63 2026-06-02 Buy
Product number Packaging Price Buy
39183 1mg $63 Buy
39183 5mg $294 Buy
CS-0835118 1mg $212 Buy
CS-0835118 5mg $636 Buy
AA02AG23 1mg $63 Buy

ATM Inhibitor-7 Chemical Properties, Uses, Production

Uses

ATM Inhibitor-7 is a potent and selective ataxia-telangiectasia mutated (ATM) inhibitor with an IC50 value of 1.0 nM. ATM Inhibitor-7 induces Apoptosis and cell cycle arrest at G2/M phase when combinanted with CPT-11 (HY-16562). ATM Inhibitor-7 combines with CPT-11 shows antitumor activity[1].

in vivo

ATM Inhibitor-7 (5 mg/kg; i.p.; once daily for 23 days) combines with CPT-11 (5 mg/kg, i.p.; once a week) shows antitumor activity in mice[1].

Animal Model:Female nude mice (SW620 tumor xenograft model)[1]
Dosage:5 mg/kg; CPT-11 (5 mg/kg, i.p.; once a week)
Administration:I.p.; once daily for 23 days
Result:Increased the antitumor activity of CPT-11.

IC 50

ATM: 1.0 nM (IC50)

References

[1] Shiyu Zhang, et al. Discovery of [1,2,3]Triazolo[4,5-c]quinoline Derivatives as a New Class of Ataxia-Telangiectasia Mutated Kinase Inhibitors. ACS Med. Chem. Lett. 2023.

ATM Inhibitor-7 Preparation Products And Raw materials

Raw materials

Preparation Products

ATM Inhibitor-7 Suppliers

Global Suppliers ( 1)
Supplier Tel Email Country ProdList Advantage
Cayman Chemical Company -- sales@caymanchem.com China 6808 58
Supplier Advantage
Cayman Chemical Company 58

3033712-80-7 (ATM Inhibitor-7) Related Search:

ATM Inhibitor-7 AZD-1390 AZD-0156 KU 60019 KU-55933
CP466722

1of2

ATM Inhibitor-7 1-Propanamine, N,N-dimethyl-3-[[5-[1-[(1R)-1-phenylethyl]-1H-1,2,3-triazolo[4,5-c]quinolin-8-yl]-2-pyridinyl]oxy]- 3033712-80-7