ChemicalBook >> CAS DataBase List >>W4275

W4275

W4275 structure

CAS No.: 3051650-00-8

Chemical Name:: W4275

Synonyms: W4275;2-Quinazolinecarbonitrile, 6-methoxy-4-[[1-(1-methylethyl)-4-piperidinyl]amino]-7-[3-(4-morpholinyl)propoxy]-

CBNumber:: CB014907894

Molecular Formula:: C25H36N6O3

Molecular Weight:: 468.59

MDL Number:

MOL File:: 3051650-00-8.mol

MSDS File:: SDS

Last updated:2025-04-18 09:51:26

Request For Quotation

W4275 Properties

Boiling point	659.2±65.0 °C(predicted)
Density	1.23±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
pka	9.51±0.50(predicted)

W4275 price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
ChemScene	CS-1224447	W4275 98.93%	3051650-00-8	5mg	$607	2026-06-04	Buy
ChemScene	CS-1224447	W4275 98.93%	3051650-00-8	10mg	$975	2026-06-04	Buy
ChemScene	CS-1224447	W4275 98.93%	3051650-00-8	25mg	$2004	2026-06-04	Buy
ChemScene	CS-1224447	W4275 98.93%	3051650-00-8	50mg	$3196	2026-06-04	Buy
Arctom	HY-168035	W4275 98.93%	3051650-00-8	10mM*1mLinDMSO(Solid+Solvent)	$521	2026-05-26	Buy

Product number	Packaging	Price	Buy
CS-1224447	5mg	$607	Buy
CS-1224447	10mg	$975	Buy
CS-1224447	25mg	$2004	Buy
CS-1224447	50mg	$3196	Buy
HY-168035	10mM*1mLinDMSO(Solid+Solvent)	$521	Buy

W4275 Chemical Properties, Uses, Production

Uses

W4275 (Compound 42) is a selective NSD2 inhibitor with oral activity, showing an IC50 value of 17 nM. W4275 exhibits antiproliferative activity with an IC50 of 230 nM against RS411 cells and significantly inhibits tumor growth in the RS411 tumor xenograft model. Pharmacokinetic analysis in mice demonstrates that W4275 has good oral bioavailability (F of 27.34%). W4275 holds promise for use in cancer research[1].

IC 50

NSD2: 17 nM (IC₅₀)

References

[1] Wei J, et al. Discovery of a Highly Potent and Selective Inhibitor Targeting Protein Lysine Methyltransferase NSD2. J Med Chem. 2024 Sep 4. DOI:10.1021/acs.jmedchem.4c00639

W4275 Preparation Products And Raw materials

Raw materials

Preparation Products

W4275 Suppliers

Global Suppliers ( 3)

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Beckham Medical Technology Co., Ltd	13816613772	huahero21@sina.com	China	2994	55
Guangzhou Younan Technology Co., Ltd	020-82000279 18988941452	YN_research@163.com	China	2984	58
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	29873	58

Supplier	Advantage
Shanghai Beckham Medical Technology Co., Ltd	55
Guangzhou Younan Technology Co., Ltd	58
TargetMol Chemicals Inc.	58

3051650-00-8 (W4275) Related Search:

W4275 UNC0638 W4022 UNC 0638 MS0124

2-Cyclohexyl-6-methoxy-N-methyl-N-[1-(1-methylethyl)-4-piperidinyl]-7-[3-(1-pyrrolidinyl)propoxy]-4-quinazolinamine

1of2

W4275 2-Quinazolinecarbonitrile, 6-methoxy-4-[[1-(1-methylethyl)-4-piperidinyl]amino]-7-[3-(4-morpholinyl)propoxy]- 3051650-00-8