Motesanib
- CAS No.
- 453562-69-1
- Chemical Name:
- Motesanib
- Synonyms
- D06678;CS-1108;motesanib;Motesanib Base;AMG 706; AMG-706;AMG-706(Motesanib);Motesanib, 10 mM in DMSO;Motesanib (AMG-706) Base);2,4-Imidazolidinedione,5-(3-bromophenyl)-6-methyl-;N-(3,3-dimethylindolin-6-yl)-2-(pyridin-4-ylmethylamino)nicotinamide
- CBNumber:
- CB01518524
- Molecular Formula:
- C22H23N5O
- Molecular Weight:
- 373.45
- MDL Number:
- MFCD10567689
- MOL File:
- 453562-69-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 147-150°C |
|---|---|
| Boiling point | 517.3±50.0 °C(Predicted) |
| Density | 1.251 |
| storage temp. | Refrigerator |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | White powder solid. |
| pka | 11.75±0.40(Predicted) |
| color | Pale Yellow |
| InChI | InChI=1S/C22H23N5O/c1-22(2)14-26-19-12-16(5-6-18(19)22)27-21(28)17-4-3-9-24-20(17)25-13-15-7-10-23-11-8-15/h3-12,26H,13-14H2,1-2H3,(H,24,25)(H,27,28) |
| InChIKey | RAHBGWKEPAQNFF-UHFFFAOYSA-N |
| SMILES | C1(NCC2C=CN=CC=2)=NC=CC=C1C(NC1=CC2=C(C=C1)C(C)(C)CN2)=O |
| FDA UNII | U1JK633AYI |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P362+P364-P302+P352-P305+P351+P338 |
| HS Code | 2933399990 |
Motesanib price More Price(56)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | M3717 | Motesanib | 453562-69-1 | 100MG | $232 | 2026-04-30 | Buy |
| TRC | TRC-M732500-50MG | Motesanib | 453562-69-1 | 50mg | $223 | 2026-06-03 | Buy |
| TRC | TRC-M732500-10MG | Motesanib | 453562-69-1 | 10mg | $84 | 2026-06-03 | Buy |
| TRC | TRC-M732500-100MG | Motesanib | 453562-69-1 | 100mg | $415 | 2026-06-03 | Buy |
| Usbiological | 017881 | Motesanib | 453562-69-1 | 5mg | $496 | 2026-06-03 | Buy |
Motesanib Chemical Properties, Uses, Production
Chemical Properties
Pale Yellow Solid
Uses
Motesanib Diphosphate (AMG-706) is a potent ATP-competitive inhibitor of VEGFR1/2/3, PDGFR, c-Kit and Ret with IC50 of 2 nM/3 nM/6 nM, 84 nM, 8 nM and 59 nM, respectively.
Uses
Motesanib is an oral angiogenesis inhibitor, demonstrates clinical efficacy in advanced thymoma.
Definition
ChEBI: Motesanib is a pyridinecarboxamide.
in vivo
Motesanib (100 mg/kg) significantly inhibits VEGF-induced vascular permeability in a time-dependent manner. Oral administration of Motesanib twice daily or once daily potently inhibits, in a dose-dependent manner, VEGF-induced angiogenesis using the rat corneal model with ED50 of 2.1 mg/kg and 4.9 mg/kg, respectively. Motesanib induces a dose-dependent tumor regression of established A431 xenografts by selectively targeting neovascularization in tumor cells[1]. Motesanib in combination with radiation displays significant anti-tumor activity in head and neck squamous cell carcinoma (HNSCC) xenograft models[2]. Motesanib treatment also induces significant dose-dependent reductions in tumor growth and blood vessel density of MCF-7, MDA-MB-231, or Cal-51 xenografts, which can be markedly enhanced when combined with docetaxel or tamoxifen[3].
target
VEGFR1
IC 50
VEGFR1: 2 nM (IC50); VEGFR2: 3 nM (IC50); VEGFR3: 6 nM (IC50)
Motesanib Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 9778 | 55 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 5996 | 61 |
| LGM Pharma | 1-(800)-881-8210 | inquiries@lgmpharma.com | United States | 2110 | 70 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| Jinan Trio PharmaTech Co., Ltd. | 0531-88811783 | sales@trio-pharmatech.com | China | 1856 | 62 |
| Xi’an chemsoar Medical Technology Co., ltd | 029-86538357 | China | 234 | 57 | |
| Dalian Meilun Biotech Co., Ltd. | 0411-62910999 13889544652 | sales@meilune.com | China | 4765 | 58 |
| Beijing Yisiyan Technology Research Center | 010-56645598 13366904824; | bjkaida@163.com | China | 1597 | 59 |
| Nanjing JinruiJiuAn Biotechnology Co., Ltd. | 025-58196018 800028039 | sales@fartop.net | China | 2227 | 55 |
View Latest Price from Motesanib manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-06-30 | Motesanib
453562-69-1
|
1KG | 98% | 1000kg | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2021-07-02 | motesanib
453562-69-1
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd | ||
 |
2020-01-03 | Motesanib
453562-69-1
|
$1.00 | 1g | 99% | 100kgs | Career Henan Chemical Co |
