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ERK Inhibitor

ERK Inhibitor Structure
ERK Inhibitor structure
CAS No.
1049738-54-6
Chemical Name:
ERK Inhibitor
Synonyms
ERK-IN-4;ERK Inhibitor - CAS 1049738-54-6 - Calbiochem;3-(2-aminoethyl)-5-[(4-ethoxyphenyl)methylene]-2,4-thiazolidinedione,monohydrochloride;(5Z)-3-(2-aminoethyl)-5-[(4-ethoxyphenyl)methylidene]-1,3-thiazolidine-2,4-dione:hydrochloride
CBNumber:
CB13136749
Molecular Formula:
C14H17ClN2O3S
Molecular Weight:
328.81
MDL Number:
MFCD09038681
MOL File:
1049738-54-6.mol
Last updated:2025-09-20 20:09:13
Product description Number Pack Size Price
ERK Inhibitor The ERK Inhibitor, also referenced under CAS 1049738-54-6, controls the biological activity of ERK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applica 328006-M 1 unit $133
ERK Inhibitor ≥95% 15944 500μg $32
ERK Inhibitor ≥95% 15944 1mg $50
ERK Inhibitor ≥95% 15944 5mg $117
ErkInhibitor 9473CW 5mg $228
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ERK Inhibitor Properties

storage temp. +2C to +8C
solubility DMSO: 2 mg/ml
form Light yellow solid
color Off-white to yellow
UNSPSC Code 12352200

ERK Inhibitor price More Price(5)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 328006-M ERK Inhibitor The ERK Inhibitor, also referenced under CAS 1049738-54-6, controls the biological activity of ERK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applica 1049738-54-6 1 unit $133 2025-07-31 Buy
Cayman Chemical 15944 ERK Inhibitor ≥95% 1049738-54-6 500μg $32 2024-03-01 Buy
Cayman Chemical 15944 ERK Inhibitor ≥95% 1049738-54-6 1mg $50 2024-03-01 Buy
Cayman Chemical 15944 ERK Inhibitor ≥95% 1049738-54-6 5mg $117 2024-03-01 Buy
AK Scientific 9473CW ErkInhibitor 1049738-54-6 5mg $228 2021-12-16 Buy
Product number Packaging Price Buy
328006-M 1 unit $133 Buy
15944 500μg $32 Buy
15944 1mg $50 Buy
15944 5mg $117 Buy
9473CW 5mg $228 Buy

ERK Inhibitor Chemical Properties,Uses,Production

Description

ERK inhibitor is a cell-permeable inhibitor that binds ERK2 near its docking domain (KD = 5 μM). This prevents its interaction with protein substrates without inhibiting catalytic activity. ERK inhibitor blocks ERK-specific phosphorylation of ribosomal S6 kinase-1 and ternary complex factor Elk-1 but does not affect ERK1/2 phosphorylation by MEK1/2. Presumably through its effects on ERK, ERK inhibitor completely prevents proliferation of HeLa cells (IC50 = 15-20 μM), A549 lung carcinoma cells (IC50 = 25 μM), Sum-159 estrogen receptor-negative breast cancer cells and HT1080 fibrosarcoma cells.

Uses

ERK-IN-4 is an ERK inhibitor binds preferentially to ERK2 with a Kd of 5 μM. ERK-IN-4 specificity inhibits ERK Rsk-1 and Elk-1 phosphorylation. ERK-IN-4 has little effect on ERK protein phosphorylation by its upstream activator MEK1/2[1].

General Description

A cell-permeable and reversible thiazolidinedione compound that displays anti-proliferative properties (IC50 ≤ 25 μM in HeLa, A549, and SUM-159 tumor cells). Preferentially binds to ERK2 with a KD of ~5 μM and prevents its interaction with protein substrates. Shown to block ERK-mediated phosphorylation of ribosomal S6 kinase-1 (RSK-1) and ternary complex factor Elk-1 in HeLa cells, while exhibiting little effect on ERK1/2 phosphorylation by MEK1/2.

Biochem/physiol Actions

Primary TargetERK

IC 50

ERK2: 5 μM (Kd)

References

[1] Chad N Hancock, et al. Identification of novel extracellular signal-regulated kinase docking domain inhibitors. J Med Chem. 2005 Jul 14;48(14):4586-95. DOI:10.1021/jm0501174

ERK Inhibitor Preparation Products And Raw materials

Raw materials

Preparation Products

ERK Inhibitor Suppliers

Global( 39)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32435 58
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd 		+8618829768577 gao490372054@gamil.com China 1249 58
Wuhan Topule Biopharmaceutical Co., Ltd 		+8618327326525 masar@topule.com China 8467 58
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd 		+8618791163155 18791163155@163.com China 3401 58
Aladdin Scientific 		tp@aladdinsci.com United States 57505 58
DAYANG CHEM (HANGZHOU) CO.,LTD 		+86-88938639 +86-17705817739 info@dycnchem.com China 53900 58
ComMedX (Computational Medicine Beijing Co., Ltd.) 		+86-18519000250 +86-18519000250 zhanghu@commedx.com China 258 58
Shanghai Run-Biotech Co., Ltd. 021-57171705 13817537615 sales@run-biotech.com China 2374 58
Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51395 80
BOC Sciences 16314854226 info@bocsci.com United States 9923 65
Supplier Advantage
TargetMol Chemicals Inc. 		58
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd 		58
Wuhan Topule Biopharmaceutical Co., Ltd 		58
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd 		58
Aladdin Scientific 		58
DAYANG CHEM (HANGZHOU) CO.,LTD 		58
ComMedX (Computational Medicine Beijing Co., Ltd.) 		58
Shanghai Run-Biotech Co., Ltd. 58
Sigma-Aldrich 80
BOC Sciences 65

View Lastest Price from ERK Inhibitor manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
ERK-IN-4 pictures 2025-09-19 ERK-IN-4
1049738-54-6
 US $40.00-89.00 / mg 99.84% 10g TargetMol Chemicals Inc.
  • ERK-IN-4 pictures
  • ERK-IN-4
    1049738-54-6
  • US $40.00-89.00 / mg
  • 99.84%
  • TargetMol Chemicals Inc.

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(5Z)-3-(2-aminoethyl)-5-[(4-ethoxyphenyl)methylidene]-1,3-thiazolidine-2,4-dione:hydrochloride ERK Inhibitor - CAS 1049738-54-6 - Calbiochem 3-(2-aminoethyl)-5-[(4-ethoxyphenyl)methylene]-2,4-thiazolidinedione,monohydrochloride ERK-IN-4 1049738-54-6