3-amino-5-bromopyridine-2-carboxylic acid
- CAS No.
- 870997-85-6
- Chemical Name:
- 3-amino-5-bromopyridine-2-carboxylic acid
- Synonyms
- 3-Amino-5-bromopicolinic acid;3-Amino-5-bromopyridine-2...;3-Amino 5-Bromo 2-Carboxylic Acid;3-AMino-5-broMopyridine-2-carboxylic;3-AMino-5-broMopyridin-2-carboxylic acid;3-amino-5-bromopyridine-2-carboxylic acid;3-amino-5-bromo-2-Pyridinecarboxylic acid;2-Pyridinecarboxylic acid, 3-aMino-5-broMo-
- CBNumber:
- CB01558713
- Molecular Formula:
- C6H5BrN2O2
- Molecular Weight:
- 217.02
- MDL Number:
- MFCD09999770
- MOL File:
- 870997-85-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | >170°C (dec.) |
|---|---|
| Boiling point | 399.0±42.0 °C(Predicted) |
| Density | 1.909±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 4.15±0.10(Predicted) |
| color | Yellow |
| InChI | InChI=1S/C6H5BrN2O2/c7-3-1-4(8)5(6(10)11)9-2-3/h1-2H,8H2,(H,10,11) |
| InChIKey | GXXIHPZAIYKHGG-UHFFFAOYSA-N |
| SMILES | C1(C(O)=O)=NC=C(Br)C=C1N |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P280-P301+P312-P261 |
| HazardClass | IRRITANT |
| HS Code | 2933399990 |
3-amino-5-bromopyridine-2-carboxylic acid price More Price(55)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | ADE000138 | 3-Amino-5-bromopicolinic acid Aldrich | 870997-85-6 | 1g | $761 | 2023-01-07 | Buy |
| TRC | TRC-A594990-250MG | 3-Amino-5-bromopyridine-2-carboxylic acid | 870997-85-6 | 250mg | $65 | 2026-06-03 | Buy |
| TRC | TRC-A594990-2.5G | 3-Amino-5-bromopyridine-2-carboxylic acid | 870997-85-6 | 2.5g | $269 | 2026-06-03 | Buy |
| TRC | TRC-A594990-1G | 3-Amino-5-bromopyridine-2-carboxylic acid | 870997-85-6 | 1g | $142 | 2026-06-03 | Buy |
| Apolloscientific | OR345434 | 3-Amino-5-bromopyridine-2-carboxylic acid >98% | 870997-85-6 | 1g | $21 | 2026-06-04 | Buy |
3-amino-5-bromopyridine-2-carboxylic acid Chemical Properties, Uses, Production
Uses
3-amino-5-bromopyridine-2-carboxylic acid is used in the preparation of biological reagents such as macrocyclic glucagon-like peptide 1 receptor agonists. It is also used in the preparation of pyridinamide and indoline compounds.
Synthesis
669066-89-1
870997-85-6
Step 2: Synthesis of 3-amino-5-bromopyridine-2-carboxylic acid To a 100 mL round bottom flask was added 3-amino-5-bromopyridine-2-carboxamide (1.05 g, 4.9 mmol) and aqueous sodium hydroxide solution (0.98 g dissolved in 10 mL of water, 24.5 mmol). The reaction mixture was heated to reflux temperature and stirred for 5 hours. Upon completion of the reaction, volatiles were removed by distillation under reduced pressure to give a residue. The residue was neutralized with 2N HCl at 0 °C to pH=7.0 and precipitate was precipitated. The precipitate was collected by filtration and dried to give 3-amino-5-bromopyridine-2-carboxylic acid as a light yellow solid (1 g, 95% yield). 1H NMR (300 MHz, DMSO-d6): δ 7.65 (d, J=2.1 Hz, 1H), 7.20 (d, J=2.1 Hz, 1H), 7.01-7.16 (br s, 2H). LC-MS (ESI): calculated: 215.9; measured: 217.0 [M+H]+ (RT: 0.43 min).
References
[1] Patent: WO2012/58671, 2012, A1. Location in patent: Page/Page column 117-118
[2] Patent: US2014/38952, 2014, A1. Location in patent: Page/Page column 0180-0181
[3] Patent: EP1757594, 2007, A1. Location in patent: Page/Page column 77
[4] Patent: WO2008/76425, 2008, A1. Location in patent: Page/Page column 33
[5] Patent: WO2008/130600, 2008, A2. Location in patent: Page/Page column 56
3-amino-5-bromopyridine-2-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| FUXIN QINGJISHENG SCIENCE AND TECHNOLOGY CO.,LID | 15940530539 15396717197 | 361811402@qq.com | China | 650 | 58 |
| PharmaBlock Sciences (Nanjing), Inc. | 4000255188 | sales@pharmablock.com | China | 7266 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
| Nan Jing Dirise Chemcial Co.,LTD | 025-52161033 15312098939 | 2432674894@qq.com | China | 585 | 64 |
| SpringPharma Tech Co.,Ltd | +86-25-68710855, +86-25-68710897 | sales@springpharma.net | China | 1260 | 62 |
| Dtchem Laboratories,（Gan Su）Co.,Ltd. | 18993961550 18993966060 | sales@techbiochem.com | China | 774 | 61 |
| Hangzhou Sage Chemical Co., Ltd. | +86057186818502 13588463833 | info@sagechem.com | China | 10265 | 58 |
View Latest Price from 3-amino-5-bromopyridine-2-carboxylic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2022-04-22 | 3-Amino-5-bromopicolinicacid
870997-85-6
|
98%min | 100kgs/month | Shanghai Rlavie Technology Co ltd | |||
 |
2020-01-13 | 3-amino-5-bromopyridine-2-carboxylic acid
870997-85-6
|
$1.00 | 1g | 99% | 10000KGS | Career Henan Chemical Co |
-
- 3-Amino-5-bromopicolinicacid
870997-85-6
- 98%min
- Shanghai Rlavie Technology Co ltd
-
- 3-amino-5-bromopyridine-2-carboxylic acid
870997-85-6
- $1.00
- 99%
- Career Henan Chemical Co
