2-Amino-5-bromonicotinic acid
- CAS No.
- 52833-94-0
- Chemical Name:
- 2-Amino-5-bromonicotinic acid
- Synonyms
- 2-AMINO-5-BROMOPYRIDINE-3-CARBOXYLIC ACID;2-Amino-5-bromonicotinic ...;2-AMINO-5-BROMONICOTINIC ACID;1-AMino-5-broMonicotinic acid;2-Amino-5-bromonicotonic acid;5-Bromo-2-Amino Nicotinic Acid;2-Amino-5-bromonicotinic acid 95%;2-Amino-5-bromonicotinic acid,95%;2-Amino-5-bromonicotinic acid ,97%;2-Amino-5-bromonicotinic acid USP/EP/BP
- CBNumber:
- CB0236771
- Molecular Formula:
- C6H5BrN2O2
- Molecular Weight:
- 217.02
- MDL Number:
- MFCD01860227
- MOL File:
- 52833-94-0.mol
- MSDS File:
- SDS
| Melting point | 253-255°C |
|---|---|
| Boiling point | 350.4±42.0 °C(Predicted) |
| Density | 1.909 |
| refractive index | 1.5150 (estimate) |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| pka | 2.55±0.10(Predicted) |
| form | powder |
| color | Pale yellow |
| CAS DataBase Reference | 52833-94-0(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS05 |
|---|---|
| Signal word | Danger |
| Hazard statements | H302-H312-H314-H332 |
| Precautionary statements | P260-P261-P264-P270-P271-P280-P301+P312-P301+P330+P331-P302+P352-P303+P361+P353-P304+P340-P305+P351+P338-P310-P312-P321-P322-P330-P363-P405-P501 |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 37/39-26 |
| RIDADR | UN2811 |
| HazardClass | IRRITANT |
| HS Code | 29333990 |
2-Amino-5-bromonicotinic acid price More Price(74)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 259858 | 2-Amino-5-bromonicotinic acid Asreported | 52833-94-0 | 5g | $382 | 2026-06-03 | Buy |
| Usbiological | 259858 | 2-Amino-5-bromonicotinic acid Asreported | 52833-94-0 | 10g | $542 | 2026-06-03 | Buy |
| Usbiological | 259858 | 2-Amino-5-bromonicotinic acid Asreported | 52833-94-0 | 25g | $835 | 2026-06-03 | Buy |
| Usbiological | 259858 | 2-Amino-5-bromonicotinic acid Asreported | 52833-94-0 | 50g | $1204 | 2026-06-03 | Buy |
| Usbiological | 259858 | 2-Amino-5-bromonicotinic acid Asreported | 52833-94-0 | 100g | $1720 | 2026-06-03 | Buy |
2-Amino-5-bromonicotinic acid Chemical Properties,Uses,Production
Synthesis
In a 500mL three-necked flask equipped with a stirrer and a reflux condenser, 20.7g (0.15mol) of 2-aminonicotinic acid and 80mL of acetic acid were added. The mixture was stirred at room temperature. A mixture of 40mL of acetic acid and 4.1mL of bromine (0.08mol) was added dropwise using a constant-pressure dropping funnel. Stirring continued for 4-5 hours after the addition was complete. The mixture was filtered, washed with acetic acid, dried, and the solid was heated under reflux with 100mL of methanol for 10 minutes, then allowed to stand at room temperature, filtered, and dried. 31.2g of a white solid, 2-amino-5-bromonicotinic acid, was obtained, with a yield of 96%.
1H NMR (400MHz, DMSO-d6)δ12.72(s,1H),9.05(d,J＝2.4Hz,1H),8.63(d,J＝2.4Hz,1H),8.36(s,1H).MS: m/z(ESI+)228.3[M+H]+.Uses
2-Amino-5-bromonicotinic acid is an organic intermediate that can be prepared by brominating 2-aminonicotinic acid. Literature reports that 2-amino-5-bromonicotinic acid can be used to prepare 6-pyrazole-substituted quinazoline compounds and their derivatives. These compounds exhibit high tyrosine kinase inhibitory activity and strong inhibitory activity against human breast cancer cells and lung adenocarcinoma cells.
Chemical Properties
Light yellow powder
References
[1] Patent: US6369056, 2002, B1
[2] Patent: US6399593, 2002, B1
[3] Patent: US2006/30583, 2006, A1. Location in patent: Page/Page column 113
[4] Patent: CN106565684, 2017, A. Location in patent: Paragraph 0177; 0178; 0179; 0180
[5] Patent: WO2014/209727, 2014, A1. Location in patent: Page/Page column 60-61
2-Amino-5-bromonicotinic acid Preparation Products And Raw materials
Raw materials
1of3
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| ShangHai DEMO Chemical Co.,Ltd | 400-021-7337 2355568890 | sales@demochem.com | China | 2569 | 57 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
View Lastest Price from 2-Amino-5-bromonicotinic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-03-20 | 2-Amino-5-bromonicotinic acid
52833-94-0
|
1KG | 99% | 20 mt | Hebei Chuanghai Biotechnology Co., Ltd | ||
 |
2025-05-23 | 2-Amino-5-bromonicotinic acid
52833-94-0
|
$10.00 | 1kg | 99% | 20 ton | Hebei Zhuanglai Chemical Trading Co Ltd | |
 |
2025-04-04 | 2-Amino-5-bromonicotinic acid
52833-94-0
|
1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. |
-
- 2-Amino-5-bromonicotinic acid
52833-94-0
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- 2-Amino-5-bromonicotinic acid
52833-94-0
- $10.00
- 99%
- Hebei Zhuanglai Chemical Trading Co Ltd
-
- 2-Amino-5-bromonicotinic acid
52833-94-0
- 98%
- Henan Aochuang Chemical Co.,Ltd.
