2-(Chloromethyl)thiophene
- CAS No.
- 765-50-4
- Chemical Name:
- 2-(Chloromethyl)thiophene
- Synonyms
- Thenyl chloride;2-(chloromethyl)thiophene;THIOPHENE, 2-(CHLOROMETHYL)-;2-(Chloromethyl)thiophene###765-50-4;2-(Chloromethyl)thiophene ISO 9001：2015 REACH;2-(Chloromethyl)thiophene, 33% w/w solution in toluene
- CBNumber:
- CB0238735
- Molecular Formula:
- C5H5ClS
- Molecular Weight:
- 132.61
- MDL Number:
- MFCD00797972
- MOL File:
- 765-50-4.mol
- MSDS File:
- SDS
| Boiling point | 80-81 °C(Press: 18 Torr) |
|---|---|
| Density | 1.243±0.06 g/cm3(Predicted) |
| storage temp. | Amber Vial, -20°C Freezer |
| solubility | Acetonitrile, Chloroform |
| form | Oil |
| color | Colourless |
| CAS DataBase Reference | 765-50-4(CAS DataBase Reference) |
| FDA UNII | 7QQ8C6HMR7 |
| NIST Chemistry Reference | Thiophene, 2-(chloromethyl)-(765-50-4) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| RIDADR | 1993 |
| HazardClass | 3 |
| PackingGroup | Ⅲ |
| HS Code | 2933399990 |
2-(Chloromethyl)thiophene price More Price(17)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | TRC-B419458-5G | 2-(Chloromethyl)thiophene | 765-50-4 | 5g | $2037 | 2026-06-03 | Buy |
| TRC | TRC-B419458-500MG | 2-(Chloromethyl)thiophene | 765-50-4 | 500mg | $262 | 2026-06-03 | Buy |
| Chemenu | CM108580 | 2-(chloromethyl)thiophene 95% | 765-50-4 | 100mg | $265 | 2026-05-26 | Buy |
| Chemenu | CM108580 | 2-(chloromethyl)thiophene 95% | 765-50-4 | 250mg | $374 | 2026-05-26 | Buy |
| Chemenu | CM108580 | 2-(chloromethyl)thiophene 95% | 765-50-4 | 1g | $1104 | 2026-05-26 | Buy |
2-(Chloromethyl)thiophene Chemical Properties, Uses, Production
Chemical Properties
Colorless Liquid
Synthesis
636-72-6
765-50-4
The general procedure for the synthesis of 2-chloromethylthiophene from 2-thiophenemethanol was as follows: 2-thiophenemethanol (5,58 g, 509 mmol) and pyridine (60 g, 763 mmol) were dissolved in 600 mL of anhydrous dichloromethane at 0 °C, and thionyl chloride was added slowly and dropwise. The reaction mixture was stirred at 0°C for 1 hour, then brought to room temperature and continued to stir overnight. Upon completion of the reaction, the reaction was quenched by the addition of 500 mL of water. The organic layer was separated and the aqueous layer was extracted twice with 300 mL of dichloromethane. The organic layers were combined and washed sequentially with 600 mL of 5% aqueous sodium bicarbonate and 300 mL of brine. The organic layer was dried with anhydrous sodium sulfate and concentrated to give 40 g of 2-chloromethylthiophene (6) as an oil in 60% yield.
References
[1] European Journal of Medicinal Chemistry, 2001, vol. 36, # 11-12, p. 873 - 886
[2] European Journal of Pharmaceutical Sciences, 2002, vol. 16, # 1-2, p. 15 - 28
[3] European Journal of Organic Chemistry, 2014, vol. 2014, # 11, p. 2365 - 2370
[4] Tetrahedron, 1998, vol. 54, # 25, p. 6999 - 7012
[5] Synthetic Communications, 2005, vol. 35, # 15, p. 2079 - 2083
2-(Chloromethyl)thiophene Preparation Products And Raw materials
Raw materials
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Preparation Products
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| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Beijing HwrkChemical Technology Co., Ltd | 89508211 18501085097 | sales.bj@hwrkchemical.com | China | 9407 | 55 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Sphinx Scientific Laboratory (Tianjin) Co., Ltd. | 022-66211289-843 13672102692 | contact@sphinxpharm.com | China | 361 | 62 |
| Atop-Pharma (Shanghai) Technology Co., Ltd. | +86 (21) 5196-9732 | China | 996 | 57 | |
| T&W GROUP | 021-61551611 13296011611 | contact@trustwe.com | China | 9884 | 58 |
| Shanghai Topbiochem Technology Co., Ltd | 021-58170097 | info@topbiochem.com | China | 9510 | 58 |
| Nanjing Norris-Pharm Technology Co., Ltd | 13901585132 | sales@norris-pharm.com | China | 8869 | 55 |
| Shanghai Jian Chao Chemical Technology Co., Ltd. | 150-2103-5486 18017383231 | 983544897@qq.com | China | 9336 | 55 |
| UHN Shanghai Research & Development Co., Ltd. | 021-58958002 18930822973 | sales@uhnshanghai.com | China | 997 | 58 |
| Shanghai Yolne Chemical Co., Ltd. | 021-62960152 | 934678158@qq.com | China | 9886 | 55 |
View Latest Price from 2-(Chloromethyl)thiophene manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-02-02 | 2-(Chloromethyl)thiophene
765-50-4
|
$1.00 | 1g | 99% | 50tons | Shaanxi Dideu Medichem Co. Ltd | |
 |
2025-12-24 | 2-(Chloromethyl)thiophene
765-50-4
|
1KG | 99.0% | 1000 tons | Shaanxi Dideu Medichem Co. Ltd | ||
 |
2021-08-12 | 2-(Chloromethyl)thiophene
765-50-4
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd |
-
- 2-(Chloromethyl)thiophene
765-50-4
- $1.00
- 99%
- Shaanxi Dideu Medichem Co. Ltd
-
- 2-(Chloromethyl)thiophene
765-50-4
- $0.10
- 99.0%
- Shaanxi Dideu Medichem Co. Ltd
-
- 2-(Chloromethyl)thiophene
765-50-4
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
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